DegronMD

Uniprot ID: E9PAV3

Source protein: Nascent polypeptide-associated complex subunit alpha, muscle-specific form

Source gene: NACA

Class: DEG_SCF_FBW7_1

Location: 231:238

E3 ligase: FBXW7

DEGRON score: 0.9786

ASA_SCORE: 94.3875

COIL: 0.9431

CONS_SCORE: 0.3342

DSS_SCORE: 0.3795

HELIX: 0.0148

FCONS_SCORE: 1.1734

RIG_SCORE: 0.7581

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A242T	TCGA-17-Z011	LUAD	TCGA	PQTTPTTT	DEG_SCF_FBW7_1	0.2222
p.A221V	TCGA-2W-A8YY	CESC	TCGA	PQTTPTTT	DEG_SCF_FBW7_1	0.0556
p.A221V	DO223732	CESC	ICGC	PQTTPTTT	DEG_SCF_FBW7_1	0.0556
p.P231L	TCGA-W3-A825	SKCM	TCGA	PQTTPTTT	DEG_SCF_FBW7_1	0.6471
p.P231L	DO51272	SKCM	ICGC	PQTTPTTT	DEG_SCF_FBW7_1	0.6471
p.T238N	DO228924	LICA	ICGC	PQTTPTTT	DEG_SCF_FBW7_1	0.7055
p.A221D	DO229022	LICA	ICGC	PQTTPTTT	DEG_SCF_FBW7_1	0.0556
p.P235L	ACH-000600	Kidney Cancer	CCLE	PQTTPTTT	DEG_SCF_FBW7_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	231:238	PQTTPTTT	FBXW7	0.9786	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons