DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PRAELVALT
Uniprot ID:
P56696
Source protein:
Potassium voltage-gated channel subfamily KQT member 4
Source gene:
KCNQ4
Class:
DEG_APCC_DBOX_1
Location:
19:27
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7552
ASA_SCORE:
70.5556
COIL:
0.2126
CONS_SCORE:
0.3712
DSS_SCORE:
0.6287
HELIX:
0.7783
FCONS_SCORE:
1.0182
RIG_SCORE:
0.7528
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with KCNQ4 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PRAELVALT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P56696
Potassium voltage-gated channel subfamily KQT member 4
DEG_APCC_DBOX_1
19:27
PRAELVALT
APC,CDC20,FZR1
0.7552
More...