DegronMD

Uniprot ID: A2A3L6

Source protein: Tetratricopeptide repeat protein 24

Source gene: TTC24

Class: DEG_APCC_DBOX_1

Location: 527:535

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9077

ASA_SCORE: 57.3444

COIL: 0.7543

CONS_SCORE: 0.3886

DSS_SCORE: 0.4901

HELIX: 0.0413

FCONS_SCORE: 1.1157

RIG_SCORE: 0.6694

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P527L	TCGA-44-6144	LUAD	TCGA	PRAHLPFVG	DEG_APCC_DBOX_1	0.6471
p.P527L	DO24190	LUAD	ICGC	PRAHLPFVG	DEG_APCC_DBOX_1	0.6471
p.I522V	TCGA-AP-A0LE	UCEC	TCGA	PRAHLPFVG	DEG_APCC_DBOX_1	0.1944
p.I522V	DO43418	UCEC	ICGC	PRAHLPFVG	DEG_APCC_DBOX_1	0.1944
p.E542K	TCGA-AP-A1DK	UCEC	TCGA	PRAHLPFVG	DEG_APCC_DBOX_1	0.1389
p.E542K	DO42033	UCEC	ICGC	PRAHLPFVG	DEG_APCC_DBOX_1	0.1389
p.A520T	TCGA-EE-A29S	SKCM	TCGA	PRAHLPFVG	DEG_APCC_DBOX_1	0.1389
p.A520T	DO37936	SKCM	ICGC	PRAHLPFVG	DEG_APCC_DBOX_1	0.1389
p.A541V	TCGA-T2-A6X2	HNSC	TCGA	PRAHLPFVG	DEG_APCC_DBOX_1	0.1667
p.A541V	DO219071	HNSC	ICGC	PRAHLPFVG	DEG_APCC_DBOX_1	0.1667
p.F533C	DO8264	COAD	ICGC	PRAHLPFVG	DEG_APCC_DBOX_1	0.5996
p.P532A	DO229047	LICA	ICGC	PRAHLPFVG	DEG_APCC_DBOX_1	0.6392
p.P525L	DO50970	LICA	ICGC	PRAHLPFVG	DEG_APCC_DBOX_1	0.2778
p.A529V	DO50970	LICA	ICGC	PRAHLPFVG	DEG_APCC_DBOX_1	0.5825
p.A529V	SIDM01318	Hepatocellular Carcinoma	GDSC	PRAHLPFVG	DEG_APCC_DBOX_1	0.5825
p.A529V	ACH-001318	Liver Cancer	CCLE	PRAHLPFVG	DEG_APCC_DBOX_1	0.5825
p.G537C	SIDM02049	Pancreatic Carcinoma	GDSC	PRAHLPFVG	DEG_APCC_DBOX_1	0.2778
p.G518D	SIDM00499	Prostate Carcinoma	GDSC	PRAHLPFVG	DEG_APCC_DBOX_1	0.0833
p.G518D	ACH-000956	Prostate Cancer	CCLE	PRAHLPFVG	DEG_APCC_DBOX_1	0.0833
p.G518D	22RV1	prostate	COSMIC	PRAHLPFVG	DEG_APCC_DBOX_1	0.0833
p.I522N	SIDM01117	Small Cell Lung Carcinoma	GDSC	PRAHLPFVG	DEG_APCC_DBOX_1	0.1944
p.I522N	ACH-002176	Lung Cancer	CCLE	PRAHLPFVG	DEG_APCC_DBOX_1	0.1944
p.K519E	SIDM00781	Colorectal Carcinoma	GDSC	PRAHLPFVG	DEG_APCC_DBOX_1	0.2222
p.K519E	SIDM00780	Colorectal Carcinoma	GDSC	PRAHLPFVG	DEG_APCC_DBOX_1	0.2222
p.K519E	ACH-000967	Colon/Colorectal Cancer	CCLE	PRAHLPFVG	DEG_APCC_DBOX_1	0.2222
p.K519E	ACH-001199	Colon/Colorectal Cancer	CCLE	PRAHLPFVG	DEG_APCC_DBOX_1	0.2222
p.K519E	SNU-C2B	large_intestine	COSMIC	PRAHLPFVG	DEG_APCC_DBOX_1	0.2222
p.Y543S	CAL-27	upper_aerodigestive_tract	COSMIC	PRAHLPFVG	DEG_APCC_DBOX_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRAHLPFVG

Degron related mutations and impact score

Drug responses associated with TTC24 mutations

All proteins holding degron of PRAHLPFVG

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A2A3L6	Tetratricopeptide repeat protein 24	DEG_APCC_DBOX_1	527:535	PRAHLPFVG	APC,CDC20,FZR1	0.9077	More...