DegronMD - A2A3L6(TTC24)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V447I	TCGA-32-4719	GBM	TCGA	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	432:439	Mutation rewiring degron network	0.1111
p.V447I	DO11406	GBM	ICGC	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	432:439	Mutation rewiring degron network	0.1111
p.P527L	TCGA-44-6144	LUAD	TCGA	PRAHLPFVG	DEG_APCC_DBOX_1	527:535	Mutation altering degron motif	0.6471
p.P527L	DO24190	LUAD	ICGC	PRAHLPFVG	DEG_APCC_DBOX_1	527:535	Mutation altering degron motif	0.6471
p.G435E	TCGA-66-2767	LUSC	TCGA	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	432:439	Mutation altering degron motif	0.6087
p.G435E	DO26713	LUSC	ICGC	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	432:439	Mutation altering degron motif	0.6087
p.E434D	TCGA-67-3771	LUAD	TCGA	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	432:439	Mutation altering degron motif	0.5647
p.E434D	DO25797	LUAD	ICGC	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	432:439	Mutation altering degron motif	0.5647
p.I522V	TCGA-AP-A0LE	UCEC	TCGA	PRAHLPFVG	DEG_APCC_DBOX_1	527:535	Mutation rewiring degron network	0.1944
p.I522V	DO43418	UCEC	ICGC	PRAHLPFVG	DEG_APCC_DBOX_1	527:535	Mutation rewiring degron network	0.1944
p.E542K	TCGA-AP-A1DK	UCEC	TCGA	PRAHLPFVG	DEG_APCC_DBOX_1	527:535	Mutation rewiring degron network	0.1389
p.E542K	DO42033	UCEC	ICGC	PRAHLPFVG	DEG_APCC_DBOX_1	527:535	Mutation rewiring degron network	0.1389
p.A520T	TCGA-EE-A29S	SKCM	TCGA	PRAHLPFVG	DEG_APCC_DBOX_1	527:535	Mutation rewiring degron network	0.1389
p.A520T	DO37936	SKCM	ICGC	PRAHLPFVG	DEG_APCC_DBOX_1	527:535	Mutation rewiring degron network	0.1389
p.A541V	TCGA-T2-A6X2	HNSC	TCGA	PRAHLPFVG	DEG_APCC_DBOX_1	527:535	Mutation rewiring degron network	0.1667
p.A541V	DO219071	HNSC	ICGC	PRAHLPFVG	DEG_APCC_DBOX_1	527:535	Mutation rewiring degron network	0.1667
p.A440T	TCGA-W3-AA1Q	SKCM	TCGA	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	432:439	Mutation rewiring degron network	0.3056
p.A440T	DO219487	SKCM	ICGC	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	432:439	Mutation rewiring degron network	0.3056
p.F533C	DO8264	COAD	ICGC	PRAHLPFVG	DEG_APCC_DBOX_1	527:535	Mutation altering degron motif	0.5996
p.G446V	DO229032	LICA	ICGC	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	432:439	Mutation rewiring degron network	0.1389
p.G428C	DO229038	LICA	ICGC	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	432:439	Mutation rewiring degron network	0.2222
p.P532A	DO229047	LICA	ICGC	PRAHLPFVG	DEG_APCC_DBOX_1	527:535	Mutation altering degron motif	0.6392
p.P525L	DO50970	LICA	ICGC	PRAHLPFVG	DEG_APCC_DBOX_1	527:535	Mutation rewiring degron network	0.2778
p.A529V	DO50970	LICA	ICGC	PRAHLPFVG	DEG_APCC_DBOX_1	527:535	Mutation altering degron motif	0.5825
p.A529V	SIDM01318	Hepatocellular Carcinoma	GDSC	PRAHLPFVG	DEG_APCC_DBOX_1	527:535	Mutation altering degron motif	0.5825
p.A529V	ACH-001318	Liver Cancer	CCLE	PRAHLPFVG	DEG_APCC_DBOX_1	527:535	Mutation altering degron motif	0.5825
p.E434K	DO229459	SKCA	ICGC	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	432:439	Mutation altering degron motif	0.7022
p.G537C	SIDM02049	Pancreatic Carcinoma	GDSC	PRAHLPFVG	DEG_APCC_DBOX_1	527:535	Mutation rewiring degron network	0.2778
p.G518D	SIDM00499	Prostate Carcinoma	GDSC	PRAHLPFVG	DEG_APCC_DBOX_1	527:535	Mutation rewiring degron network	0.0833
p.G518D	ACH-000956	Prostate Cancer	CCLE	PRAHLPFVG	DEG_APCC_DBOX_1	527:535	Mutation rewiring degron network	0.0833
p.G518D	22RV1	prostate	COSMIC	PRAHLPFVG	DEG_APCC_DBOX_1	527:535	Mutation rewiring degron network	0.0833
p.I522N	SIDM01117	Small Cell Lung Carcinoma	GDSC	PRAHLPFVG	DEG_APCC_DBOX_1	527:535	Mutation rewiring degron network	0.1944
p.I522N	ACH-002176	Lung Cancer	CCLE	PRAHLPFVG	DEG_APCC_DBOX_1	527:535	Mutation rewiring degron network	0.1944
p.K519E	SIDM00781	Colorectal Carcinoma	GDSC	PRAHLPFVG	DEG_APCC_DBOX_1	527:535	Mutation substituting flanking lysine	0.2222
p.K519E	SIDM00780	Colorectal Carcinoma	GDSC	PRAHLPFVG	DEG_APCC_DBOX_1	527:535	Mutation substituting flanking lysine	0.2222
p.K519E	ACH-000967	Colon/Colorectal Cancer	CCLE	PRAHLPFVG	DEG_APCC_DBOX_1	527:535	Mutation substituting flanking lysine	0.2222
p.K519E	ACH-001199	Colon/Colorectal Cancer	CCLE	PRAHLPFVG	DEG_APCC_DBOX_1	527:535	Mutation substituting flanking lysine	0.2222
p.K519E	SNU-C2B	large intestine	COSMIC	PRAHLPFVG	DEG_APCC_DBOX_1	527:535	Mutation substituting flanking lysine	0.2222
p.P437L	SIDM00117	Non-Small Cell Lung Carcinoma	GDSC	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	432:439	Mutation altering degron motif	0.7582
p.P437L	ACH-000837	Lung Cancer	CCLE	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	432:439	Mutation altering degron motif	0.7582
p.P437L	NCI-H322M	lung	COSMIC	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	432:439	Mutation altering degron motif	0.7582
p.E434Q	SIDM00971	Breast Carcinoma	GDSC	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	432:439	Mutation altering degron motif	0.6744
p.E434Q	ACH-000828	Breast Cancer	CCLE	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	432:439	Mutation altering degron motif	0.6744
p.E434Q	ZR-75-30	breast	COSMIC	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	432:439	Mutation altering degron motif	0.6744
p.G422R	SIDM01131	Small Cell Lung Carcinoma	GDSC	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	432:439	Mutation rewiring degron network	0.0556
p.G422R	ACH-000355	Lung Cancer	CCLE	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	432:439	Mutation rewiring degron network	0.0556
p.G422R	NCI-H82	lung	COSMIC	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	432:439	Mutation rewiring degron network	0.0556
p.G435V	SIDM01470	Acute Myeloid Leukemia	GDSC	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	432:439	Mutation altering degron motif	0.6421
p.G422E	ACH-001518	Endometrial/Uterine Cancer	CCLE	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	432:439	Mutation rewiring degron network	0.0556
p.Y543S	CAL-27	upper aerodigestive tract	COSMIC	PRAHLPFVG	DEG_APCC_DBOX_1	527:535	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TTC24

UniProt ID: A2A3L6

Entrez ID: 164118

Protein name: Tetratricopeptide repeat protein 24 (TPR repeat protein 24)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TTC24 in