DegronMD

Uniprot ID: A2A3L6

Source protein: Tetratricopeptide repeat protein 24

Source gene: TTC24

Class: DEG_SCF_SKP2-CKS1_1

Location: 432:439

E3 ligase: SKP2,CSK1

DEGRON score: 0.7369

ASA_SCORE: 70.3375

COIL: 0.5631

CONS_SCORE: 0.3672

DSS_SCORE: 0.7085

HELIX: 0.4068

FCONS_SCORE: 1.0249

RIG_SCORE: 0.6036

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V447I	TCGA-32-4719	GBM	TCGA	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	0.1111
p.V447I	DO11406	GBM	ICGC	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	0.1111
p.G435E	TCGA-66-2767	LUSC	TCGA	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	0.6087
p.G435E	DO26713	LUSC	ICGC	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	0.6087
p.E434D	TCGA-67-3771	LUAD	TCGA	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	0.5647
p.E434D	DO25797	LUAD	ICGC	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	0.5647
p.A440T	TCGA-W3-AA1Q	SKCM	TCGA	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	0.3056
p.A440T	DO219487	SKCM	ICGC	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	0.3056
p.G446V	DO229032	LICA	ICGC	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	0.1389
p.G428C	DO229038	LICA	ICGC	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	0.2222
p.E434K	DO229459	SKCA	ICGC	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	0.7022
p.P437L	SIDM00117	Non-Small Cell Lung Carcinoma	GDSC	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	0.7582
p.P437L	ACH-000837	Lung Cancer	CCLE	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	0.7582
p.P437L	NCI-H322M	lung	COSMIC	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	0.7582
p.E434Q	SIDM00971	Breast Carcinoma	GDSC	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	0.6744
p.E434Q	ACH-000828	Breast Cancer	CCLE	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	0.6744
p.E434Q	ZR-75-30	breast	COSMIC	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	0.6744
p.G422R	SIDM01131	Small Cell Lung Carcinoma	GDSC	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	0.0556
p.G422R	ACH-000355	Lung Cancer	CCLE	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	0.0556
p.G422R	NCI-H82	lung	COSMIC	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	0.0556
p.G435V	SIDM01470	Acute Myeloid Leukemia	GDSC	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	0.6421
p.G422E	ACH-001518	Endometrial/Uterine Cancer	CCLE	QAEGTPAK	DEG_SCF_SKP2-CKS1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A2A3L6	Tetratricopeptide repeat protein 24	DEG_SCF_SKP2-CKS1_1	432:439	QAEGTPAK	SKP2,CSK1	0.7369	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons