DegronMD

Uniprot ID: A6NIN4

Source protein: RING finger protein 227

Source gene: RNF227

Class: DEG_APCC_DBOX_1

Location: 87:95

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6004

ASA_SCORE: 67.6333

COIL: 0.6764

CONS_SCORE: 0.8842

DSS_SCORE: 0.3807

HELIX: 0.2669

FCONS_SCORE: 0.94

RIG_SCORE: 0.7342

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A92P	EN	endometrium	COSMIC	PRGGLTEMA	DEG_APCC_DBOX_1	0.7503
p.A92P	TC-YIK	cervix	COSMIC	PRGGLTEMA	DEG_APCC_DBOX_1	0.7503
p.A92P	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	PRGGLTEMA	DEG_APCC_DBOX_1	0.7503
p.A104V	BC-1	haematopoietic_and_lymphoid_tissue	COSMIC	PRGGLTEMA	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NIN4	RING finger protein 227	DEG_APCC_DBOX_1	87:95	PRGGLTEMA	APC,CDC20,FZR1	0.6004	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons