DegronMD

Uniprot ID: Q9UQ05

Source protein: Potassium voltage-gated channel subfamily H member 4

Source gene: KCNH4

Class: DEG_APCC_DBOX_1

Location: 754:762

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9354

ASA_SCORE: 79.1556

COIL: 0.7921

CONS_SCORE: 0.3329

DSS_SCORE: 0.4092

HELIX: 0.1294

FCONS_SCORE: 1.0427

RIG_SCORE: 0.6877

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E764K	TCGA-5M-AAT6	COAD	TCGA	PRGSLVSLL	DEG_APCC_DBOX_1	0.2778
p.E764K	DO223703	COAD	ICGC	PRGSLVSLL	DEG_APCC_DBOX_1	0.2778
p.F769L	TCGA-DF-A2KV	UCEC	TCGA	PRGSLVSLL	DEG_APCC_DBOX_1	0.1389
p.F769L	DO219771	UCEC	ICGC	PRGSLVSLL	DEG_APCC_DBOX_1	0.1389
p.P754H	DO229035	LICA	ICGC	PRGSLVSLL	DEG_APCC_DBOX_1	0.6583
p.F769V	DO36556	READ	ICGC	PRGSLVSLL	DEG_APCC_DBOX_1	0.1389
p.S757F	SIDM00007	Other Solid Cancers	GDSC	PRGSLVSLL	DEG_APCC_DBOX_1	0.6871
p.S757F	ACH-001550	Skin Cancer	CCLE	PRGSLVSLL	DEG_APCC_DBOX_1	0.6871

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UQ05	Potassium voltage-gated channel subfamily H member 4	DEG_APCC_DBOX_1	754:762	PRGSLVSLL	APC,CDC20,FZR1	0.9354	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons