DegronMD - Q9UQ05(KCNH4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R173H	TCGA-17-Z015	LUAD	TCGA	SRTVLHRLT	DEG_APCC_DBOX_1	172:180	Mutation altering degron motif	0.8244
p.R173H	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	SRTVLHRLT	DEG_APCC_DBOX_1	172:180	Mutation altering degron motif	0.8244
p.R173H	ACH-000951	Lung Cancer	CCLE	SRTVLHRLT	DEG_APCC_DBOX_1	172:180	Mutation altering degron motif	0.8244
p.R173H	NCI-H2342	lung	COSMIC	SRTVLHRLT	DEG_APCC_DBOX_1	172:180	Mutation altering degron motif	0.8244
p.Q188H	TCGA-49-AAR2	LUAD	TCGA	SRTVLHRLT	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.1111
p.Q188H	DO218918	LUAD	ICGC	SRTVLHRLT	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.1111
p.R178Q	TCGA-59-2349	OV	TCGA	SRTVLHRLT	DEG_APCC_DBOX_1	172:180	Mutation altering degron motif	0.6218
p.R178Q	DO233896	GACA	ICGC	SRTVLHRLT	DEG_APCC_DBOX_1	172:180	Mutation altering degron motif	0.6218
p.R178Q	DO28621	OV	ICGC	SRTVLHRLT	DEG_APCC_DBOX_1	172:180	Mutation altering degron motif	0.6218
p.E764K	TCGA-5M-AAT6	COAD	TCGA	PRGSLVSLL	DEG_APCC_DBOX_1	754:762	Mutation rewiring degron network	0.2778
p.E764K	DO223703	COAD	ICGC	PRGSLVSLL	DEG_APCC_DBOX_1	754:762	Mutation rewiring degron network	0.2778
p.R166W	TCGA-B5-A0JY	UCEC	TCGA	SRTVLHRLT	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.1667
p.R166W	DO43041	UCEC	ICGC	SRTVLHRLT	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.1667
p.R185L	TCGA-CC-A8HV	LIHC	TCGA	SRTVLHRLT	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.1944
p.R185L	DO52189	LIHC	ICGC	SRTVLHRLT	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.1944
p.F769L	TCGA-DF-A2KV	UCEC	TCGA	PRGSLVSLL	DEG_APCC_DBOX_1	754:762	Mutation rewiring degron network	0.1389
p.F769L	DO219771	UCEC	ICGC	PRGSLVSLL	DEG_APCC_DBOX_1	754:762	Mutation rewiring degron network	0.1389
p.R185H	DO230343	COCA	ICGC	SRTVLHRLT	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.1944
p.T174A	DO233168	GACA	ICGC	SRTVLHRLT	DEG_APCC_DBOX_1	172:180	Mutation altering degron motif	0.6028
p.A168D	DO229026	LICA	ICGC	SRTVLHRLT	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.2222
p.H177Q	DO229036	LICA	ICGC	SRTVLHRLT	DEG_APCC_DBOX_1	172:180	Mutation altering degron motif	0.647
p.P754H	DO229035	LICA	ICGC	PRGSLVSLL	DEG_APCC_DBOX_1	754:762	Mutation altering degron motif	0.6583
p.F769V	DO36556	READ	ICGC	PRGSLVSLL	DEG_APCC_DBOX_1	754:762	Mutation rewiring degron network	0.1389
p.R166Q	SIDM00588	Oral Cavity Carcinoma	GDSC	SRTVLHRLT	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.1667
p.R166Q	ACH-000546	Head and Neck Cancer	CCLE	SRTVLHRLT	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.1667
p.R166Q	HSC-4	upper aerodigestive tract	COSMIC	SRTVLHRLT	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.1667
p.S757F	SIDM00007	Other Solid Cancers	GDSC	PRGSLVSLL	DEG_APCC_DBOX_1	754:762	Mutation altering degron motif	0.6871
p.S757F	ACH-001550	Skin Cancer	CCLE	PRGSLVSLL	DEG_APCC_DBOX_1	754:762	Mutation altering degron motif	0.6871
p.G190C	SIDM00217	Colorectal Carcinoma	GDSC	SRTVLHRLT	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.0556
p.G190C	ACH-000999	Colon/Colorectal Cancer	CCLE	SRTVLHRLT	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.0556
p.G190C	SNU-1040	large intestine	COSMIC	SRTVLHRLT	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.0556
p.T162N	NCI-H630	large intestine	COSMIC	SRTVLHRLT	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.0556

Kaplan plot for KCNH4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KCNH4

UniProt ID: Q9UQ05

Entrez ID: 23415

Protein name: Potassium voltage-gated channel subfamily H member 4 (Brain-specific eag-like channel 2) (BEC2) (Ether-a-go-go-like potassium channel 1) (ELK channel 1) (ELK1) (Voltage-gated potassium channel subunit Kv12.3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KCNH4 in