DegronMD

Uniprot ID: Q9UQ05

Source protein: Potassium voltage-gated channel subfamily H member 4

Source gene: KCNH4

Class: DEG_APCC_DBOX_1

Location: 172:180

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9981

ASA_SCORE: 104.2778

COIL: 0.7328

CONS_SCORE: 0.459

DSS_SCORE: 0.5677

HELIX: 0.1449

FCONS_SCORE: 1.3394

RIG_SCORE: 0.748

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R173H	TCGA-17-Z015	LUAD	TCGA	SRTVLHRLT	DEG_APCC_DBOX_1	0.8244
p.R173H	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	SRTVLHRLT	DEG_APCC_DBOX_1	0.8244
p.R173H	ACH-000951	Lung Cancer	CCLE	SRTVLHRLT	DEG_APCC_DBOX_1	0.8244
p.R173H	NCI-H2342	lung	COSMIC	SRTVLHRLT	DEG_APCC_DBOX_1	0.8244
p.Q188H	TCGA-49-AAR2	LUAD	TCGA	SRTVLHRLT	DEG_APCC_DBOX_1	0.1111
p.Q188H	DO218918	LUAD	ICGC	SRTVLHRLT	DEG_APCC_DBOX_1	0.1111
p.R178Q	TCGA-59-2349	OV	TCGA	SRTVLHRLT	DEG_APCC_DBOX_1	0.6218
p.R178Q	DO233896	GACA	ICGC	SRTVLHRLT	DEG_APCC_DBOX_1	0.6218
p.R178Q	DO28621	OV	ICGC	SRTVLHRLT	DEG_APCC_DBOX_1	0.6218
p.R166W	TCGA-B5-A0JY	UCEC	TCGA	SRTVLHRLT	DEG_APCC_DBOX_1	0.1667
p.R166W	DO43041	UCEC	ICGC	SRTVLHRLT	DEG_APCC_DBOX_1	0.1667
p.R185L	TCGA-CC-A8HV	LIHC	TCGA	SRTVLHRLT	DEG_APCC_DBOX_1	0.1944
p.R185L	DO52189	LIHC	ICGC	SRTVLHRLT	DEG_APCC_DBOX_1	0.1944
p.R185H	DO230343	COCA	ICGC	SRTVLHRLT	DEG_APCC_DBOX_1	0.1944
p.T174A	DO233168	GACA	ICGC	SRTVLHRLT	DEG_APCC_DBOX_1	0.6028
p.A168D	DO229026	LICA	ICGC	SRTVLHRLT	DEG_APCC_DBOX_1	0.2222
p.H177Q	DO229036	LICA	ICGC	SRTVLHRLT	DEG_APCC_DBOX_1	0.647
p.R166Q	SIDM00588	Oral Cavity Carcinoma	GDSC	SRTVLHRLT	DEG_APCC_DBOX_1	0.1667
p.R166Q	ACH-000546	Head and Neck Cancer	CCLE	SRTVLHRLT	DEG_APCC_DBOX_1	0.1667
p.R166Q	HSC-4	upper_aerodigestive_tract	COSMIC	SRTVLHRLT	DEG_APCC_DBOX_1	0.1667
p.G190C	SIDM00217	Colorectal Carcinoma	GDSC	SRTVLHRLT	DEG_APCC_DBOX_1	0.0556
p.G190C	ACH-000999	Colon/Colorectal Cancer	CCLE	SRTVLHRLT	DEG_APCC_DBOX_1	0.0556
p.G190C	SNU-1040	large_intestine	COSMIC	SRTVLHRLT	DEG_APCC_DBOX_1	0.0556
p.T162N	NCI-H630	large_intestine	COSMIC	SRTVLHRLT	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UQ05	Potassium voltage-gated channel subfamily H member 4	DEG_APCC_DBOX_1	172:180	SRTVLHRLT	APC,CDC20,FZR1	0.9981	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRTVLHRLT

Degron related mutations and impact score

Drug responses associated with KCNH4 mutations

All proteins holding degron of SRTVLHRLT