DegronMD

Uniprot ID: P49327

Source protein: Fatty acid synthase

Source gene: FASN

Class: DEG_SCF_FBW7_1

Location: 824:831

E3 ligase: FBXW7

DEGRON score: 0.6069

ASA_SCORE: 49.7125

COIL: 0.8485

CONS_SCORE: 0.6625

DSS_SCORE: 0.2829

HELIX: 0.0314

FCONS_SCORE: 0.9254

RIG_SCORE: 0.7314

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L829I	TCGA-A5-A0G1	UCEC	TCGA	PRGTPLIS	DEG_SCF_FBW7_1	0.6063
p.L829I	DO42472	UCEC	ICGC	PRGTPLIS	DEG_SCF_FBW7_1	0.6063
p.S839N	DO225130	BRCA	ICGC	PRGTPLIS	DEG_SCF_FBW7_1	0.1111
p.P824S	SIDM00742	Non-Small Cell Lung Carcinoma	GDSC	PRGTPLIS	DEG_SCF_FBW7_1	0.6752
p.P824S	ACH-000021	Lung Cancer	CCLE	PRGTPLIS	DEG_SCF_FBW7_1	0.6752
p.P824S	ACH-000033	Lung Cancer	CCLE	PRGTPLIS	DEG_SCF_FBW7_1	0.6752
p.P824S	NCI-H1693	lung	COSMIC	PRGTPLIS	DEG_SCF_FBW7_1	0.6752
p.H838Y	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	PRGTPLIS	DEG_SCF_FBW7_1	0.1389
p.H838Y	H513	pleura	COSMIC	PRGTPLIS	DEG_SCF_FBW7_1	0.1389
p.G826E	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PRGTPLIS	DEG_SCF_FBW7_1	0.6087
p.G826E	ACH-001127	Leukemia	CCLE	PRGTPLIS	DEG_SCF_FBW7_1	0.6087
p.G826E	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PRGTPLIS	DEG_SCF_FBW7_1	0.6087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49327	Fatty acid synthase	DEG_SCF_FBW7_1	824:831	PRGTPLIS	FBXW7	0.6069	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons