DegronMD - P49327(FASN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P972L	TCGA-50-5941	LUAD	TCGA	PTPNPT	DEG_SCF_FBW7_1	975:980	Mutation rewiring degron network	0.25
p.P972L	TCGA-BR-8382	STAD	TCGA	PTPNPT	DEG_SCF_FBW7_1	975:980	Mutation rewiring degron network	0.25
p.P972L	DO25528	LUAD	ICGC	PTPNPT	DEG_SCF_FBW7_1	975:980	Mutation rewiring degron network	0.25
p.P972L	DO47925	STAD	ICGC	PTPNPT	DEG_SCF_FBW7_1	975:980	Mutation rewiring degron network	0.25
p.L829I	TCGA-A5-A0G1	UCEC	TCGA	PRGTPLIS	DEG_SCF_FBW7_1	824:831	Mutation altering degron motif	0.6063
p.L829I	DO42472	UCEC	ICGC	PRGTPLIS	DEG_SCF_FBW7_1	824:831	Mutation altering degron motif	0.6063
p.A1491S	TCGA-A6-5660	COAD	TCGA	SSTSHVPEV	DEG_COP1_1	1478:1486	Mutation rewiring degron network	0.1944
p.A1491S	DO7972	COAD	ICGC	SSTSHVPEV	DEG_COP1_1	1478:1486	Mutation rewiring degron network	0.1944
p.P1484L	TCGA-AX-A3G8	UCEC	TCGA	SSTSHVPEV	DEG_COP1_1	1478:1486	Mutation altering degron motif	0.7582
p.P1484L	DO41014	UCEC	ICGC	SSTSHVPEV	DEG_COP1_1	1478:1486	Mutation altering degron motif	0.7582
p.E981D	TCGA-EE-A2GN	SKCM	TCGA	PTPNPT	DEG_SCF_FBW7_1	975:980	Mutation rewiring degron network	0.3056
p.E981D	DO37896	SKCM	ICGC	PTPNPT	DEG_SCF_FBW7_1	975:980	Mutation rewiring degron network	0.3056
p.P979H	TCGA-FS-A1Z4	SKCM	TCGA	PTPNPT	DEG_SCF_FBW7_1	975:980	Mutation altering degron motif	0.6583
p.P979H	DO37462	SKCM	ICGC	PTPNPT	DEG_SCF_FBW7_1	975:980	Mutation altering degron motif	0.6583
p.P979S	TCGA-W3-AA1V	SKCM	TCGA	PTPNPT	DEG_SCF_FBW7_1	975:980	Mutation altering degron motif	0.5641
p.P979S	DO51276	SKCM	ICGC	PTPNPT	DEG_SCF_FBW7_1	975:980	Mutation altering degron motif	0.5641
p.N1476K	TCGA-X6-A8C2	SARC	TCGA	SSTSHVPEV	DEG_COP1_1	1478:1486	Mutation rewiring degron network	0.2778
p.N1476K	DO220318	SARC	ICGC	SSTSHVPEV	DEG_COP1_1	1478:1486	Mutation rewiring degron network	0.2778
p.P966H	TCGA-XF-AAN3	BLCA	TCGA	PTPNPT	DEG_SCF_FBW7_1	975:980	Mutation rewiring degron network	0.0833
p.P966H	DO219053	BLCA	ICGC	PTPNPT	DEG_SCF_FBW7_1	975:980	Mutation rewiring degron network	0.0833
p.E1492K	DO225046	BRCA	ICGC	SSTSHVPEV	DEG_COP1_1	1478:1486	Mutation rewiring degron network	0.1667
p.S839N	DO225130	BRCA	ICGC	PRGTPLIS	DEG_SCF_FBW7_1	824:831	Mutation rewiring degron network	0.1111
p.V1483I	DO222765	COCA	ICGC	SSTSHVPEV	DEG_COP1_1	1478:1486	Mutation altering degron motif	0.7076
p.N978S	DO234315	ESAD	ICGC	PTPNPT	DEG_SCF_FBW7_1	975:980	Mutation altering degron motif	0.5958
p.N978S	SIDM01005	Acute Myeloid Leukemia	GDSC	PTPNPT	DEG_SCF_FBW7_1	975:980	Mutation altering degron motif	0.5958
p.N978S	KASUMI-1	haematopoietic and lymphoid tissue	COSMIC	PTPNPT	DEG_SCF_FBW7_1	975:980	Mutation altering degron motif	0.5958
p.H1482N	DO228952	LICA	ICGC	SSTSHVPEV	DEG_COP1_1	1478:1486	Mutation altering degron motif	0.6312
p.H1482N	DO229034	LICA	ICGC	SSTSHVPEV	DEG_COP1_1	1478:1486	Mutation altering degron motif	0.6312
p.D965E	DO229031	LICA	ICGC	PTPNPT	DEG_SCF_FBW7_1	975:980	Mutation rewiring degron network	0.0556
p.P982T	DO229037	LICA	ICGC	PTPNPT	DEG_SCF_FBW7_1	975:980	Mutation rewiring degron network	0.2778
p.P975L	DO220860	MELA	ICGC	PTPNPT	DEG_SCF_FBW7_1	975:980	Mutation altering degron motif	0.6471
p.E981K	DO220879	MELA	ICGC	PTPNPT	DEG_SCF_FBW7_1	975:980	Mutation rewiring degron network	0.3056
p.E1485K	DO222363	MELA	ICGC	SSTSHVPEV	DEG_COP1_1	1478:1486	Mutation altering degron motif	0.7022
p.Q987L	SIDM00541	Colorectal Carcinoma	GDSC	PTPNPT	DEG_SCF_FBW7_1	975:980	Mutation rewiring degron network	0.1389
p.Q987L	ACH-000926	Colon/Colorectal Cancer	CCLE	PTPNPT	DEG_SCF_FBW7_1	975:980	Mutation rewiring degron network	0.1389
p.Q987L	HT55	large intestine	COSMIC	PTPNPT	DEG_SCF_FBW7_1	975:980	Mutation rewiring degron network	0.1389
p.P824S	SIDM00742	Non-Small Cell Lung Carcinoma	GDSC	PRGTPLIS	DEG_SCF_FBW7_1	824:831	Mutation altering degron motif	0.6752
p.P824S	ACH-000021	Lung Cancer	CCLE	PRGTPLIS	DEG_SCF_FBW7_1	824:831	Mutation altering degron motif	0.6752
p.P824S	ACH-000033	Lung Cancer	CCLE	PRGTPLIS	DEG_SCF_FBW7_1	824:831	Mutation altering degron motif	0.6752
p.P824S	NCI-H1693	lung	COSMIC	PRGTPLIS	DEG_SCF_FBW7_1	824:831	Mutation altering degron motif	0.6752
p.H838Y	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	PRGTPLIS	DEG_SCF_FBW7_1	824:831	Mutation rewiring degron network	0.1389
p.H838Y	H513	pleura	COSMIC	PRGTPLIS	DEG_SCF_FBW7_1	824:831	Mutation rewiring degron network	0.1389
p.R1468S	SIDM00126	Melanoma	GDSC	SSTSHVPEV	DEG_COP1_1	1478:1486	Mutation rewiring degron network	0.0556
p.R1468S	ACH-002147	Skin Cancer	CCLE	SSTSHVPEV	DEG_COP1_1	1478:1486	Mutation rewiring degron network	0.0556
p.R1468S	K2	skin	COSMIC	SSTSHVPEV	DEG_COP1_1	1478:1486	Mutation rewiring degron network	0.0556
p.G826E	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PRGTPLIS	DEG_SCF_FBW7_1	824:831	Mutation altering degron motif	0.6087
p.G826E	ACH-001127	Leukemia	CCLE	PRGTPLIS	DEG_SCF_FBW7_1	824:831	Mutation altering degron motif	0.6087
p.G826E	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PRGTPLIS	DEG_SCF_FBW7_1	824:831	Mutation altering degron motif	0.6087
p.A1491T	ACH-000751	Leukemia	CCLE	SSTSHVPEV	DEG_COP1_1	1478:1486	Mutation rewiring degron network	0.1944
p.L1474F	ACH-000965	Endometrial/Uterine Cancer	CCLE	SSTSHVPEV	DEG_COP1_1	1478:1486	Mutation rewiring degron network	0.2222
p.L1474F	RL95-2	endometrium	COSMIC	SSTSHVPEV	DEG_COP1_1	1478:1486	Mutation rewiring degron network	0.2222
p.L1472F	RL95-2	endometrium	COSMIC	SSTSHVPEV	DEG_COP1_1	1478:1486	Mutation rewiring degron network	0.1667

Kaplan plot for FASN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FASN

UniProt ID: P49327

Entrez ID: 2194

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FASN in