DegronMD

Uniprot ID: P49327

Source protein: Fatty acid synthase

Source gene: FASN

Class: DEG_COP1_1

Location: 1478:1486

E3 ligase: COP1

DEGRON score: 0.5173

ASA_SCORE: 69.1111

COIL: 0.8577

CONS_SCORE: 0.6526

DSS_SCORE: 0.3609

HELIX: 0.0801

FCONS_SCORE: 0.9983

RIG_SCORE: 0.6849

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1491S	TCGA-A6-5660	COAD	TCGA	SSTSHVPEV	DEG_COP1_1	0.1944
p.A1491S	DO7972	COAD	ICGC	SSTSHVPEV	DEG_COP1_1	0.1944
p.P1484L	TCGA-AX-A3G8	UCEC	TCGA	SSTSHVPEV	DEG_COP1_1	0.7582
p.P1484L	DO41014	UCEC	ICGC	SSTSHVPEV	DEG_COP1_1	0.7582
p.N1476K	TCGA-X6-A8C2	SARC	TCGA	SSTSHVPEV	DEG_COP1_1	0.2778
p.N1476K	DO220318	SARC	ICGC	SSTSHVPEV	DEG_COP1_1	0.2778
p.E1492K	DO225046	BRCA	ICGC	SSTSHVPEV	DEG_COP1_1	0.1667
p.V1483I	DO222765	COCA	ICGC	SSTSHVPEV	DEG_COP1_1	0.7076
p.H1482N	DO228952	LICA	ICGC	SSTSHVPEV	DEG_COP1_1	0.6312
p.H1482N	DO229034	LICA	ICGC	SSTSHVPEV	DEG_COP1_1	0.6312
p.E1485K	DO222363	MELA	ICGC	SSTSHVPEV	DEG_COP1_1	0.7022
p.R1468S	SIDM00126	Melanoma	GDSC	SSTSHVPEV	DEG_COP1_1	0.0556
p.R1468S	ACH-002147	Skin Cancer	CCLE	SSTSHVPEV	DEG_COP1_1	0.0556
p.R1468S	K2	skin	COSMIC	SSTSHVPEV	DEG_COP1_1	0.0556
p.A1491T	ACH-000751	Leukemia	CCLE	SSTSHVPEV	DEG_COP1_1	0.1944
p.L1474F	ACH-000965	Endometrial/Uterine Cancer	CCLE	SSTSHVPEV	DEG_COP1_1	0.2222
p.L1474F	RL95-2	endometrium	COSMIC	SSTSHVPEV	DEG_COP1_1	0.2222
p.L1472F	RL95-2	endometrium	COSMIC	SSTSHVPEV	DEG_COP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49327	Fatty acid synthase	DEG_COP1_1	1478:1486	SSTSHVPEV	COP1	0.5173	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons