DegronMD

Uniprot ID: P49327

Source protein: Fatty acid synthase

Source gene: FASN

Class: DEG_SCF_FBW7_1

Location: 975:980

E3 ligase: FBXW7

DEGRON score: 0.8706

ASA_SCORE: 87.6667

COIL: 0.938

CONS_SCORE: 0.6558

DSS_SCORE: 0.6013

HELIX: 0.0417

FCONS_SCORE: 0.986

RIG_SCORE: 0.6278

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P972L	TCGA-50-5941	LUAD	TCGA	PTPNPT	DEG_SCF_FBW7_1	0.25
p.P972L	TCGA-BR-8382	STAD	TCGA	PTPNPT	DEG_SCF_FBW7_1	0.25
p.P972L	DO25528	LUAD	ICGC	PTPNPT	DEG_SCF_FBW7_1	0.25
p.P972L	DO47925	STAD	ICGC	PTPNPT	DEG_SCF_FBW7_1	0.25
p.E981D	TCGA-EE-A2GN	SKCM	TCGA	PTPNPT	DEG_SCF_FBW7_1	0.3056
p.E981D	DO37896	SKCM	ICGC	PTPNPT	DEG_SCF_FBW7_1	0.3056
p.P979H	TCGA-FS-A1Z4	SKCM	TCGA	PTPNPT	DEG_SCF_FBW7_1	0.6583
p.P979H	DO37462	SKCM	ICGC	PTPNPT	DEG_SCF_FBW7_1	0.6583
p.P979S	TCGA-W3-AA1V	SKCM	TCGA	PTPNPT	DEG_SCF_FBW7_1	0.5641
p.P979S	DO51276	SKCM	ICGC	PTPNPT	DEG_SCF_FBW7_1	0.5641
p.P966H	TCGA-XF-AAN3	BLCA	TCGA	PTPNPT	DEG_SCF_FBW7_1	0.0833
p.P966H	DO219053	BLCA	ICGC	PTPNPT	DEG_SCF_FBW7_1	0.0833
p.N978S	DO234315	ESAD	ICGC	PTPNPT	DEG_SCF_FBW7_1	0.5958
p.N978S	SIDM01005	Acute Myeloid Leukemia	GDSC	PTPNPT	DEG_SCF_FBW7_1	0.5958
p.N978S	KASUMI-1	haematopoietic_and_lymphoid_tissue	COSMIC	PTPNPT	DEG_SCF_FBW7_1	0.5958
p.D965E	DO229031	LICA	ICGC	PTPNPT	DEG_SCF_FBW7_1	0.0556
p.P982T	DO229037	LICA	ICGC	PTPNPT	DEG_SCF_FBW7_1	0.2778
p.P975L	DO220860	MELA	ICGC	PTPNPT	DEG_SCF_FBW7_1	0.6471
p.E981K	DO220879	MELA	ICGC	PTPNPT	DEG_SCF_FBW7_1	0.3056
p.Q987L	SIDM00541	Colorectal Carcinoma	GDSC	PTPNPT	DEG_SCF_FBW7_1	0.1389
p.Q987L	ACH-000926	Colon/Colorectal Cancer	CCLE	PTPNPT	DEG_SCF_FBW7_1	0.1389
p.Q987L	HT55	large_intestine	COSMIC	PTPNPT	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49327	Fatty acid synthase	DEG_SCF_FBW7_1	975:980	PTPNPT	FBXW7	0.8706	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons