DegronMD

Uniprot ID: P58505

Source protein: Uncharacterized protein C21orf58

Source gene: C21orf58

Class: DEG_APCC_DBOX_1

Location: 197:205

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9978

ASA_SCORE: 86.1333

COIL: 0.9119

CONS_SCORE: 0.6801

DSS_SCORE: 0.6136

HELIX: 0.0181

FCONS_SCORE: 1.0872

RIG_SCORE: 0.7019

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I199T	TCGA-AD-A5EJ	COAD	TCGA	PRIILPTVP	DEG_APCC_DBOX_1	0.5966
p.T203M	TCGA-B5-A3FC	UCEC	TCGA	PRIILPTVP	DEG_APCC_DBOX_1	0.6312
p.P197Q	DO228974	LICA	ICGC	PRIILPTVP	DEG_APCC_DBOX_1	0.5924
p.Q205H	DO232761	PBCA	ICGC	PRIILPTVP	DEG_APCC_DBOX_1	0.7582
p.Q205L	ACH-000544	Esophageal Cancer	CCLE	PRIILPTVP	DEG_APCC_DBOX_1	0.7765

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P58505	Uncharacterized protein C21orf58	DEG_APCC_DBOX_1	197:205	PRIILPTVP	APC,CDC20,FZR1	0.9978	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons