DegronMD

Uniprot ID: Q96D46

Source protein: 60S ribosomal export protein NMD3

Source gene: NMD3

Class: DEG_APCC_DBOX_1

Location: 476:484

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9957

ASA_SCORE: 59.1444

COIL: 0.4083

CONS_SCORE: 0.5061

DSS_SCORE: 0.5336

HELIX: 0.552

FCONS_SCORE: 1.2808

RIG_SCORE: 0.771

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E482K	TCGA-56-7221	LUSC	TCGA	PRISLAEML	DEG_APCC_DBOX_1	0.591
p.E482K	DO26689	LUSC	ICGC	PRISLAEML	DEG_APCC_DBOX_1	0.591
p.R477Q	TCGA-AA-A00N	COAD	TCGA	PRISLAEML	DEG_APCC_DBOX_1	0.7329
p.R477Q	TCGA-DK-A6AW	BLCA	TCGA	PRISLAEML	DEG_APCC_DBOX_1	0.7329
p.R477Q	TCGA-EY-A1GI	UCEC	TCGA	PRISLAEML	DEG_APCC_DBOX_1	0.7329
p.R477Q	DO48566	BLCA	ICGC	PRISLAEML	DEG_APCC_DBOX_1	0.7329
p.R477Q	DO9876	COAD	ICGC	PRISLAEML	DEG_APCC_DBOX_1	0.7329
p.R477Q	DO222884	COCA	ICGC	PRISLAEML	DEG_APCC_DBOX_1	0.7329
p.R477Q	DO51493	PACA	ICGC	PRISLAEML	DEG_APCC_DBOX_1	0.7329
p.R477Q	DO36556	READ	ICGC	PRISLAEML	DEG_APCC_DBOX_1	0.7329
p.R477Q	DO41211	UCEC	ICGC	PRISLAEML	DEG_APCC_DBOX_1	0.7329
p.R477Q	SIDM00241	Breast Carcinoma	GDSC	PRISLAEML	DEG_APCC_DBOX_1	0.7329
p.R477Q	ACH-002179	Breast Cancer	CCLE	PRISLAEML	DEG_APCC_DBOX_1	0.7329
p.R477Q	OCUB-M	breast	COSMIC	PRISLAEML	DEG_APCC_DBOX_1	0.7329
p.S490F	TCGA-BF-A5EQ	SKCM	TCGA	PRISLAEML	DEG_APCC_DBOX_1	0.6111
p.S490F	DO219452	SKCM	ICGC	PRISLAEML	DEG_APCC_DBOX_1	0.6111
p.L484R	TCGA-GN-A8LK	SKCM	TCGA	PRISLAEML	DEG_APCC_DBOX_1	0.7316
p.L484R	DO51259	SKCM	ICGC	PRISLAEML	DEG_APCC_DBOX_1	0.7316
p.D471N	TCGA-VS-A8EK	CESC	TCGA	PRISLAEML	DEG_APCC_DBOX_1	0.1944
p.D471N	DO51623	CESC	ICGC	PRISLAEML	DEG_APCC_DBOX_1	0.1944
p.A481T	DO23202	LINC	ICGC	PRISLAEML	DEG_APCC_DBOX_1	0.6028
p.I478M	DO228233	MALY	ICGC	PRISLAEML	DEG_APCC_DBOX_1	0.6507
p.D472N	DO227531	PACA	ICGC	PRISLAEML	DEG_APCC_DBOX_1	0.2222
p.T494I	SIDM00660	Colorectal Carcinoma	GDSC	PRISLAEML	DEG_APCC_DBOX_1	0.0556
p.T494I	ACH-000985	Colon/Colorectal Cancer	CCLE	PRISLAEML	DEG_APCC_DBOX_1	0.0556
p.T494I	LS-411N	large_intestine	COSMIC	PRISLAEML	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96D46	60S ribosomal export protein NMD3	DEG_APCC_DBOX_1	476:484	PRISLAEML	APC,CDC20,FZR1	0.9957	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRISLAEML

Degron related mutations and impact score

Drug responses associated with NMD3 mutations

All proteins holding degron of PRISLAEML