DegronMD - Q96D46(NMD3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E482K	TCGA-56-7221	LUSC	TCGA	PRISLAEML	DEG_APCC_DBOX_1	476:484	Mutation altering degron motif	0.591
p.E482K	DO26689	LUSC	ICGC	PRISLAEML	DEG_APCC_DBOX_1	476:484	Mutation altering degron motif	0.591
p.N457D	TCGA-A5-A0VP	UCEC	TCGA	VNIYRD	LIG_APCC_ABBA_1	456:461	Mutation altering degron motif	0.5821
p.N457D	DO42600	UCEC	ICGC	VNIYRD	LIG_APCC_ABBA_1	456:461	Mutation altering degron motif	0.5821
p.R477Q	TCGA-AA-A00N	COAD	TCGA	PRISLAEML	DEG_APCC_DBOX_1	476:484	Mutation altering degron motif	0.7329
p.R477Q	TCGA-DK-A6AW	BLCA	TCGA	PRISLAEML	DEG_APCC_DBOX_1	476:484	Mutation altering degron motif	0.7329
p.R477Q	TCGA-EY-A1GI	UCEC	TCGA	PRISLAEML	DEG_APCC_DBOX_1	476:484	Mutation altering degron motif	0.7329
p.R477Q	DO48566	BLCA	ICGC	PRISLAEML	DEG_APCC_DBOX_1	476:484	Mutation altering degron motif	0.7329
p.R477Q	DO9876	COAD	ICGC	PRISLAEML	DEG_APCC_DBOX_1	476:484	Mutation altering degron motif	0.7329
p.R477Q	DO222884	COCA	ICGC	PRISLAEML	DEG_APCC_DBOX_1	476:484	Mutation altering degron motif	0.7329
p.R477Q	DO51493	PACA	ICGC	PRISLAEML	DEG_APCC_DBOX_1	476:484	Mutation altering degron motif	0.7329
p.R477Q	DO36556	READ	ICGC	PRISLAEML	DEG_APCC_DBOX_1	476:484	Mutation altering degron motif	0.7329
p.R477Q	DO41211	UCEC	ICGC	PRISLAEML	DEG_APCC_DBOX_1	476:484	Mutation altering degron motif	0.7329
p.R477Q	SIDM00241	Breast Carcinoma	GDSC	PRISLAEML	DEG_APCC_DBOX_1	476:484	Mutation altering degron motif	0.7329
p.R477Q	ACH-002179	Breast Cancer	CCLE	PRISLAEML	DEG_APCC_DBOX_1	476:484	Mutation altering degron motif	0.7329
p.R477Q	OCUB-M	breast	COSMIC	PRISLAEML	DEG_APCC_DBOX_1	476:484	Mutation altering degron motif	0.7329
p.S490F	TCGA-BF-A5EQ	SKCM	TCGA	PRISLAEML	DEG_APCC_DBOX_1	476:484	Mutation blocking phosphorylation signal	0.6111
p.S490F	DO219452	SKCM	ICGC	PRISLAEML	DEG_APCC_DBOX_1	476:484	Mutation blocking phosphorylation signal	0.6111
p.I458M	TCGA-EY-A1G8	UCEC	TCGA	VNIYRD	LIG_APCC_ABBA_1	456:461	Mutation altering degron motif	0.6507
p.I458M	DO43578	UCEC	ICGC	VNIYRD	LIG_APCC_ABBA_1	456:461	Mutation altering degron motif	0.6507
p.E447K	TCGA-G2-A3IE	BLCA	TCGA	VNIYRD	LIG_APCC_ABBA_1	456:461	Mutation rewiring degron network	0.0833
p.E447K	DO767	BLCA	ICGC	VNIYRD	LIG_APCC_ABBA_1	456:461	Mutation rewiring degron network	0.0833
p.L484R	TCGA-GN-A8LK	SKCM	TCGA	PRISLAEML	DEG_APCC_DBOX_1	476:484	Mutation altering degron motif	0.7316
p.L484R	DO51259	SKCM	ICGC	PRISLAEML	DEG_APCC_DBOX_1	476:484	Mutation altering degron motif	0.7316
p.D471N	TCGA-VS-A8EK	CESC	TCGA	PRISLAEML	DEG_APCC_DBOX_1	476:484	Mutation rewiring degron network	0.1944
p.D471N	TCGA-VS-A8EK	CESC	TCGA	VNIYRD	LIG_APCC_ABBA_1	456:461	Mutation rewiring degron network	0.0556
p.D471N	DO51623	CESC	ICGC	PRISLAEML	DEG_APCC_DBOX_1	476:484	Mutation rewiring degron network	0.1944
p.D471N	DO51623	CESC	ICGC	VNIYRD	LIG_APCC_ABBA_1	456:461	Mutation rewiring degron network	0.0556
p.E448G	DO50951	LICA	ICGC	VNIYRD	LIG_APCC_ABBA_1	456:461	Mutation rewiring degron network	0.1111
p.A481T	DO23202	LINC	ICGC	PRISLAEML	DEG_APCC_DBOX_1	476:484	Mutation altering degron motif	0.6028
p.K454I	DO50813	LIRI	ICGC	VNIYRD	LIG_APCC_ABBA_1	456:461	Mutation blocking ubiquitination signal	0.7222
p.I478M	DO228233	MALY	ICGC	PRISLAEML	DEG_APCC_DBOX_1	476:484	Mutation altering degron motif	0.6507
p.P465S	DO222644	MELA	ICGC	VNIYRD	LIG_APCC_ABBA_1	456:461	Mutation rewiring degron network	0.2222
p.V456D	DO46591	OV	ICGC	VNIYRD	LIG_APCC_ABBA_1	456:461	Mutation altering degron motif	0.7785
p.R453Q	DO33091	PACA	ICGC	VNIYRD	LIG_APCC_ABBA_1	456:461	Mutation rewiring degron network	0.25
p.D472N	DO227531	PACA	ICGC	PRISLAEML	DEG_APCC_DBOX_1	476:484	Mutation rewiring degron network	0.2222
p.N455H	SIDM00845	Burkitt's Lymphoma	GDSC	VNIYRD	LIG_APCC_ABBA_1	456:461	Mutation rewiring degron network	0.3056
p.N455H	ACH-000786	Lymphoma	CCLE	VNIYRD	LIG_APCC_ABBA_1	456:461	Mutation rewiring degron network	0.3056
p.T494I	SIDM00660	Colorectal Carcinoma	GDSC	PRISLAEML	DEG_APCC_DBOX_1	476:484	Mutation rewiring degron network	0.0556
p.T494I	ACH-000985	Colon/Colorectal Cancer	CCLE	PRISLAEML	DEG_APCC_DBOX_1	476:484	Mutation rewiring degron network	0.0556
p.T494I	LS-411N	large intestine	COSMIC	PRISLAEML	DEG_APCC_DBOX_1	476:484	Mutation rewiring degron network	0.0556
p.A451T	SIDM01686	Chronic Myelogenous Leukemia	GDSC	VNIYRD	LIG_APCC_ABBA_1	456:461	Mutation rewiring degron network	0.1944
p.E450K	SIDM01578	Bladder Carcinoma	GDSC	VNIYRD	LIG_APCC_ABBA_1	456:461	Mutation rewiring degron network	0.1667
p.E450K	ACH-000862	Bladder Cancer	CCLE	VNIYRD	LIG_APCC_ABBA_1	456:461	Mutation rewiring degron network	0.1667

Kaplan plot for NMD3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NMD3

UniProt ID: Q96D46

Entrez ID: 51068

Protein name: 60S ribosomal export protein NMD3 (hNMD3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NMD3 in