DegronMD

Uniprot ID: Q96D46

Source protein: 60S ribosomal export protein NMD3

Source gene: NMD3

Class: LIG_APCC_ABBA_1

Location: 456:461

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9958

ASA_SCORE: 70.9667

COIL: 0.5547

CONS_SCORE: 0.5143

DSS_SCORE: 0.3897

HELIX: 0.3063

FCONS_SCORE: 1.1393

RIG_SCORE: 0.7861

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V456D	DO46591	OV	ICGC	VNIYRD	LIG_APCC_ABBA_1	0.7785
p.K454I	DO50813	LIRI	ICGC	VNIYRD	LIG_APCC_ABBA_1	0.7222
p.I458M	TCGA-EY-A1G8	UCEC	TCGA	VNIYRD	LIG_APCC_ABBA_1	0.6507
p.I458M	DO43578	UCEC	ICGC	VNIYRD	LIG_APCC_ABBA_1	0.6507
p.N457D	TCGA-A5-A0VP	UCEC	TCGA	VNIYRD	LIG_APCC_ABBA_1	0.5821
p.N457D	DO42600	UCEC	ICGC	VNIYRD	LIG_APCC_ABBA_1	0.5821
p.N455H	SIDM00845	Burkitt's Lymphoma	GDSC	VNIYRD	LIG_APCC_ABBA_1	0.3056
p.N455H	ACH-000786	Lymphoma	CCLE	VNIYRD	LIG_APCC_ABBA_1	0.3056
p.R453Q	DO33091	PACA	ICGC	VNIYRD	LIG_APCC_ABBA_1	0.25
p.P465S	DO222644	MELA	ICGC	VNIYRD	LIG_APCC_ABBA_1	0.2222
p.A451T	SIDM01686	Chronic Myelogenous Leukemia	GDSC	VNIYRD	LIG_APCC_ABBA_1	0.1944
p.E450K	SIDM01578	Bladder Carcinoma	GDSC	VNIYRD	LIG_APCC_ABBA_1	0.1667
p.E450K	ACH-000862	Bladder Cancer	CCLE	VNIYRD	LIG_APCC_ABBA_1	0.1667
p.E448G	DO50951	LICA	ICGC	VNIYRD	LIG_APCC_ABBA_1	0.1111
p.E447K	TCGA-G2-A3IE	BLCA	TCGA	VNIYRD	LIG_APCC_ABBA_1	0.0833
p.E447K	DO767	BLCA	ICGC	VNIYRD	LIG_APCC_ABBA_1	0.0833
p.D471N	TCGA-VS-A8EK	CESC	TCGA	VNIYRD	LIG_APCC_ABBA_1	0.0556
p.D471N	DO51623	CESC	ICGC	VNIYRD	LIG_APCC_ABBA_1	0.0556

Showing 1 to 18 of 18 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96D46	60S ribosomal export protein NMD3	LIG_APCC_ABBA_1	456:461	VNIYRD	APC,CDC20,FZR1	0.9958	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons