DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VNIYRD
Uniprot ID:
Q96D46
Source protein:
60S ribosomal export protein NMD3
Source gene:
NMD3
Class:
LIG_APCC_ABBA_1
Location:
456:461
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9958
ASA_SCORE:
70.9667
COIL:
0.5547
CONS_SCORE:
0.5143
DSS_SCORE:
0.3897
HELIX:
0.3063
FCONS_SCORE:
1.1393
RIG_SCORE:
0.7861
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.N457D
TCGA-A5-A0VP
UCEC
TCGA
VNIYRD
LIG_APCC_ABBA_1
0.5821
p.N457D
DO42600
UCEC
ICGC
VNIYRD
LIG_APCC_ABBA_1
0.5821
p.I458M
TCGA-EY-A1G8
UCEC
TCGA
VNIYRD
LIG_APCC_ABBA_1
0.6507
p.I458M
DO43578
UCEC
ICGC
VNIYRD
LIG_APCC_ABBA_1
0.6507
p.E447K
TCGA-G2-A3IE
BLCA
TCGA
VNIYRD
LIG_APCC_ABBA_1
0.0833
p.E447K
DO767
BLCA
ICGC
VNIYRD
LIG_APCC_ABBA_1
0.0833
p.D471N
TCGA-VS-A8EK
CESC
TCGA
VNIYRD
LIG_APCC_ABBA_1
0.0556
p.D471N
DO51623
CESC
ICGC
VNIYRD
LIG_APCC_ABBA_1
0.0556
p.E448G
DO50951
LICA
ICGC
VNIYRD
LIG_APCC_ABBA_1
0.1111
p.K454I
DO50813
LIRI
ICGC
VNIYRD
LIG_APCC_ABBA_1
0.7222
p.P465S
DO222644
MELA
ICGC
VNIYRD
LIG_APCC_ABBA_1
0.2222
p.V456D
DO46591
OV
ICGC
VNIYRD
LIG_APCC_ABBA_1
0.7785
p.R453Q
DO33091
PACA
ICGC
VNIYRD
LIG_APCC_ABBA_1
0.25
p.N455H
SIDM00845
Burkitt's Lymphoma
GDSC
VNIYRD
LIG_APCC_ABBA_1
0.3056
p.N455H
ACH-000786
Lymphoma
CCLE
VNIYRD
LIG_APCC_ABBA_1
0.3056
p.A451T
SIDM01686
Chronic Myelogenous Leukemia
GDSC
VNIYRD
LIG_APCC_ABBA_1
0.1944
p.E450K
SIDM01578
Bladder Carcinoma
GDSC
VNIYRD
LIG_APCC_ABBA_1
0.1667
p.E450K
ACH-000862
Bladder Cancer
CCLE
VNIYRD
LIG_APCC_ABBA_1
0.1667
Drug responses associated with NMD3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VNIYRD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96D46
60S ribosomal export protein NMD3
LIG_APCC_ABBA_1
456:461
VNIYRD
APC,CDC20,FZR1
0.9958
More...