DegronMD

Uniprot ID: Q92529

Source protein: SHC-transforming protein 3

Source gene: SHC3

Class: DEG_APCC_DBOX_1

Location: 446:454

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9741

ASA_SCORE: 78.6667

COIL: 0.7004

CONS_SCORE: 0.4091

DSS_SCORE: 0.5237

HELIX: 0.217

FCONS_SCORE: 1.3258

RIG_SCORE: 0.7287

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M453V	TCGA-BS-A0U8	UCEC	TCGA	PRKDLFDMK	DEG_APCC_DBOX_1	0.6097
p.M453V	DO41380	UCEC	ICGC	PRKDLFDMK	DEG_APCC_DBOX_1	0.6097
p.E443D	TCGA-CN-4727	HNSC	TCGA	PRKDLFDMK	DEG_APCC_DBOX_1	0.25
p.E443D	DO14258	HNSC	ICGC	PRKDLFDMK	DEG_APCC_DBOX_1	0.25
p.A438V	DO227872	COCA	ICGC	PRKDLFDMK	DEG_APCC_DBOX_1	0.1111
p.A438V	DO52491	COCA	ICGC	PRKDLFDMK	DEG_APCC_DBOX_1	0.1111
p.A438V	DO228261	LICA	ICGC	PRKDLFDMK	DEG_APCC_DBOX_1	0.1111
p.S445R	DO228952	LICA	ICGC	PRKDLFDMK	DEG_APCC_DBOX_1	0.3056
p.S444R	DO229027	LICA	ICGC	PRKDLFDMK	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92529	SHC-transforming protein 3	DEG_APCC_DBOX_1	446:454	PRKDLFDMK	APC,CDC20,FZR1	0.9741	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons