DegronMD

Uniprot ID: Q9UHL0

Source protein: ATP-dependent RNA helicase DDX25

Source gene: DDX25

Class: DEG_APCC_DBOX_1

Location: 28:36

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.651

ASA_SCORE: 94.3556

COIL: 0.7946

CONS_SCORE: 0.2558

DSS_SCORE: 0.3298

HELIX: 0.1288

FCONS_SCORE: 1.0707

RIG_SCORE: 0.7447

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N24D	TCGA-AD-6964	COAD	TCGA	PRKNLWGIK	DEG_APCC_DBOX_1	0.2222
p.N24D	DO8360	COAD	ICGC	PRKNLWGIK	DEG_APCC_DBOX_1	0.2222
p.R41Q	TCGA-D1-A167	UCEC	TCGA	PRKNLWGIK	DEG_APCC_DBOX_1	0.1944
p.R41Q	DO40978	UCEC	ICGC	PRKNLWGIK	DEG_APCC_DBOX_1	0.1944
p.V40D	DO9042	COAD	ICGC	PRKNLWGIK	DEG_APCC_DBOX_1	0.2222
p.G45A	DO224761	COCA	ICGC	PRKNLWGIK	DEG_APCC_DBOX_1	0.0833
p.K36N	DO229027	LICA	ICGC	PRKNLWGIK	DEG_APCC_DBOX_1	0.5806
p.S46F	SIDM00584	Osteosarcoma	GDSC	PRKNLWGIK	DEG_APCC_DBOX_1	0.0556
p.S37R	SIDM00653	Small Cell Lung Carcinoma	GDSC	PRKNLWGIK	DEG_APCC_DBOX_1	0.3056
p.S37R	ACH-000514	Lung Cancer	CCLE	PRKNLWGIK	DEG_APCC_DBOX_1	0.3056
p.S37R	NCI-H1092	lung	COSMIC	PRKNLWGIK	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UHL0	ATP-dependent RNA helicase DDX25	DEG_APCC_DBOX_1	28:36	PRKNLWGIK	APC,CDC20,FZR1	0.651	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons