DegronMD

Uniprot ID: Q96MY7

Source protein: Protein FAM161B

Source gene: FAM161B

Class: DEG_APCC_DBOX_1

Location: 628:636

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.999

ASA_SCORE: 93.6444

COIL: 0.3667

CONS_SCORE: 0.3982

DSS_SCORE: 0.6258

HELIX: 0.6254

FCONS_SCORE: 1.4344

RIG_SCORE: 0.6836

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D641E	TCGA-FI-A2D5	UCEC	TCGA	PRKVLEELS	DEG_APCC_DBOX_1	0.1944
p.D641E	DO41331	UCEC	ICGC	PRKVLEELS	DEG_APCC_DBOX_1	0.1944
p.T632N	DO229018	LICA	ICGC	PRKVLEELS	DEG_APCC_DBOX_1	0.7055
p.T632N	DO229037	LICA	ICGC	PRKVLEELS	DEG_APCC_DBOX_1	0.7055
p.K618R	DO222567	MELA	ICGC	PRKVLEELS	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96MY7	Protein FAM161B	DEG_APCC_DBOX_1	628:636	PRKVLEELS	APC,CDC20,FZR1	0.999	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons