DegronMD - Q96MY7(FAM161B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R523T	TCGA-12-0829	GBM	TCGA	LKENR	DEG_APCC_KENBOX_2	518:522	Mutation rewiring degron network	0.3056
p.R523T	DO11166	GBM	ICGC	LKENR	DEG_APCC_KENBOX_2	518:522	Mutation rewiring degron network	0.3056
p.A521V	TCGA-B0-5084	KIRC	TCGA	LKENR	DEG_APCC_KENBOX_2	518:522	Mutation altering degron motif	0.6936
p.A521V	DO19713	KIRC	ICGC	LKENR	DEG_APCC_KENBOX_2	518:522	Mutation altering degron motif	0.6936
p.A521V	SIDM00282	Colorectal Carcinoma	GDSC	LKENR	DEG_APCC_KENBOX_2	518:522	Mutation altering degron motif	0.6936
p.A521V	ACH-000998	Colon/Colorectal Cancer	CCLE	LKENR	DEG_APCC_KENBOX_2	518:522	Mutation altering degron motif	0.6936
p.A521V	CW-2	large intestine	COSMIC	LKENR	DEG_APCC_KENBOX_2	518:522	Mutation altering degron motif	0.6936
p.D641E	TCGA-FI-A2D5	UCEC	TCGA	PRKVLEELS	DEG_APCC_DBOX_1	628:636	Mutation rewiring degron network	0.1944
p.D641E	DO41331	UCEC	ICGC	PRKVLEELS	DEG_APCC_DBOX_1	628:636	Mutation rewiring degron network	0.1944
p.T632N	DO229018	LICA	ICGC	PRKVLEELS	DEG_APCC_DBOX_1	628:636	Mutation altering degron motif	0.7055
p.T632N	DO229037	LICA	ICGC	PRKVLEELS	DEG_APCC_DBOX_1	628:636	Mutation altering degron motif	0.7055
p.K618R	DO222567	MELA	ICGC	PRKVLEELS	DEG_APCC_DBOX_1	628:636	Mutation rewiring degron network	0.0556
p.L509F	DO222875	MELA	ICGC	LKENR	DEG_APCC_KENBOX_2	518:522	Mutation rewiring degron network	0.0833
p.S508F	SIDM01257	Hepatocellular Carcinoma	GDSC	LKENR	DEG_APCC_KENBOX_2	518:522	Mutation substituting flanking lysine	0.1667
p.S508F	SIDM00062	Hepatocellular Carcinoma	GDSC	LKENR	DEG_APCC_KENBOX_2	518:522	Mutation substituting flanking lysine	0.1667
p.S508F	ACH-000671	Liver Cancer	CCLE	LKENR	DEG_APCC_KENBOX_2	518:522	Mutation substituting flanking lysine	0.1667
p.S508F	ACH-002395	Liver Cancer	CCLE	LKENR	DEG_APCC_KENBOX_2	518:522	Mutation substituting flanking lysine	0.1667
p.S508F	HUH-6-clone5	liver	COSMIC	LKENR	DEG_APCC_KENBOX_2	518:522	Mutation substituting flanking lysine	0.1667

Kaplan plot for FAM161B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM161B

UniProt ID: Q96MY7

Entrez ID: 145483

Protein name: Protein FAM161B

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM161B in