DegronMD

Uniprot ID: Q96MY7

Source protein: Protein FAM161B

Source gene: FAM161B

Class: DEG_APCC_KENBOX_2

Location: 518:522

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9635

ASA_SCORE: 125.52

COIL: 0.4408

CONS_SCORE: 0.8547

DSS_SCORE: 0.4911

HELIX: 0.5698

FCONS_SCORE: 1.2519

RIG_SCORE: 0.6955

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R523T	TCGA-12-0829	GBM	TCGA	LKENR	DEG_APCC_KENBOX_2	0.3056
p.R523T	DO11166	GBM	ICGC	LKENR	DEG_APCC_KENBOX_2	0.3056
p.A521V	TCGA-B0-5084	KIRC	TCGA	LKENR	DEG_APCC_KENBOX_2	0.6936
p.A521V	DO19713	KIRC	ICGC	LKENR	DEG_APCC_KENBOX_2	0.6936
p.A521V	SIDM00282	Colorectal Carcinoma	GDSC	LKENR	DEG_APCC_KENBOX_2	0.6936
p.A521V	ACH-000998	Colon/Colorectal Cancer	CCLE	LKENR	DEG_APCC_KENBOX_2	0.6936
p.A521V	CW-2	large_intestine	COSMIC	LKENR	DEG_APCC_KENBOX_2	0.6936
p.L509F	DO222875	MELA	ICGC	LKENR	DEG_APCC_KENBOX_2	0.0833
p.S508F	SIDM01257	Hepatocellular Carcinoma	GDSC	LKENR	DEG_APCC_KENBOX_2	0.1667
p.S508F	SIDM00062	Hepatocellular Carcinoma	GDSC	LKENR	DEG_APCC_KENBOX_2	0.1667
p.S508F	ACH-000671	Liver Cancer	CCLE	LKENR	DEG_APCC_KENBOX_2	0.1667
p.S508F	ACH-002395	Liver Cancer	CCLE	LKENR	DEG_APCC_KENBOX_2	0.1667
p.S508F	HUH-6-clone5	liver	COSMIC	LKENR	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96MY7	Protein FAM161B	DEG_APCC_KENBOX_2	518:522	LKENR	APC,CDC20,FZR1	0.9635	More...
Q9BUG6	Zinc finger and SCAN domain-containing protein 5A	DEG_APCC_KENBOX_2	225:229	LKENR	APC,CDC20,FZR1	0.5671	More...
Q8NA47	Coiled-coil domain-containing protein 63	DEG_APCC_KENBOX_2	535:539	LKENR	APC,CDC20,FZR1	0.5383	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons