DegronMD

Uniprot ID: Q8NA47

Source protein: Coiled-coil domain-containing protein 63

Source gene: CCDC63

Class: DEG_APCC_KENBOX_2

Location: 535:539

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5383

ASA_SCORE: 116.2

COIL: 0.5984

CONS_SCORE: 0.2443

DSS_SCORE: 0.3264

HELIX: 0.3824

FCONS_SCORE: 0.6792

RIG_SCORE: 0.7671

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G545R	TCGA-17-Z055	LUAD	TCGA	LKENR	DEG_APCC_KENBOX_2	0.1667
p.G545R	SIDM00850	Gastric Carcinoma	GDSC	LKENR	DEG_APCC_KENBOX_2	0.1667
p.G545R	AGS	stomach	COSMIC	LKENR	DEG_APCC_KENBOX_2	0.1667
p.R544C	TCGA-19-1787	GBM	TCGA	LKENR	DEG_APCC_KENBOX_2	0.1944
p.P549S	TCGA-44-5644	LUAD	TCGA	LKENR	DEG_APCC_KENBOX_2	0.0556
p.P549S	DO25153	LUAD	ICGC	LKENR	DEG_APCC_KENBOX_2	0.0556
p.E542G	TCGA-A5-A1OF	UCEC	TCGA	LKENR	DEG_APCC_KENBOX_2	0.25
p.R539Q	TCGA-AA-3845	COAD	TCGA	LKENR	DEG_APCC_KENBOX_2	0.6218
p.S547G	TCGA-BA-4077	HNSC	TCGA	LKENR	DEG_APCC_KENBOX_2	0.1111
p.S547G	DO15647	HNSC	ICGC	LKENR	DEG_APCC_KENBOX_2	0.1111
p.V543M	TCGA-DD-AAVV	LIHC	TCGA	LKENR	DEG_APCC_KENBOX_2	0.2222
p.D531N	TCGA-EI-6917	READ	TCGA	LKENR	DEG_APCC_KENBOX_2	0.2222
p.D531N	TCGA-EO-A22R	UCEC	TCGA	LKENR	DEG_APCC_KENBOX_2	0.2222
p.E542A	TCGA-EO-A3AV	UCEC	TCGA	LKENR	DEG_APCC_KENBOX_2	0.25
p.S540I	DO228976	LICA	ICGC	LKENR	DEG_APCC_KENBOX_2	0.3056
p.Y533H	SIDM01608	Endometrial Carcinoma	GDSC	LKENR	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96MY7	Protein FAM161B	DEG_APCC_KENBOX_2	518:522	LKENR	APC,CDC20,FZR1	0.9635	More...
Q9BUG6	Zinc finger and SCAN domain-containing protein 5A	DEG_APCC_KENBOX_2	225:229	LKENR	APC,CDC20,FZR1	0.5671	More...
Q8NA47	Coiled-coil domain-containing protein 63	DEG_APCC_KENBOX_2	535:539	LKENR	APC,CDC20,FZR1	0.5383	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons