DegronMD - Q9BUG6(ZSCAN5A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E227K	TCGA-22-1000	LUSC	TCGA	LKENR	DEG_APCC_KENBOX_2	225:229	Mutation altering degron motif	0.7022
p.E227K	TCGA-EE-A181	SKCM	TCGA	LKENR	DEG_APCC_KENBOX_2	225:229	Mutation altering degron motif	0.7022
p.E227K	DO27060	LUSC	ICGC	LKENR	DEG_APCC_KENBOX_2	225:229	Mutation altering degron motif	0.7022
p.E227K	DO37444	SKCM	ICGC	LKENR	DEG_APCC_KENBOX_2	225:229	Mutation altering degron motif	0.7022
p.R216K	TCGA-22-1000	LUSC	TCGA	LKENR	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.0833
p.R216K	DO27060	LUSC	ICGC	LKENR	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.0833
p.E230K	TCGA-A2-A0EV	BRCA	TCGA	LKENR	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.3056
p.E230K	DO4942	BRCA	ICGC	LKENR	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.3056
p.A148T	TCGA-A5-A0G2	UCEC	TCGA	VRDDLKDVS	DEG_APCC_DBOX_1	154:162	Mutation rewiring degron network	0.1667
p.A148T	DO41235	UCEC	ICGC	VRDDLKDVS	DEG_APCC_DBOX_1	154:162	Mutation rewiring degron network	0.1667
p.V161M	TCGA-AO-A128	BRCA	TCGA	VRDDLKDVS	DEG_APCC_DBOX_1	154:162	Mutation altering degron motif	0.6097
p.V161M	DO5326	BRCA	ICGC	VRDDLKDVS	DEG_APCC_DBOX_1	154:162	Mutation altering degron motif	0.6097
p.R155T	TCGA-E2-A152	BRCA	TCGA	VRDDLKDVS	DEG_APCC_DBOX_1	154:162	Mutation altering degron motif	0.7876
p.E227V	TCGA-EE-A181	SKCM	TCGA	LKENR	DEG_APCC_KENBOX_2	225:229	Mutation altering degron motif	0.7693
p.T236S	TCGA-F7-A622	HNSC	TCGA	LKENR	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.1389
p.T236S	DO49039	HNSC	ICGC	LKENR	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.1389
p.S152C	TCGA-G6-A8L6	KIRC	TCGA	VRDDLKDVS	DEG_APCC_DBOX_1	154:162	Mutation rewiring degron network	0.2778
p.S152C	DO50649	KIRC	ICGC	VRDDLKDVS	DEG_APCC_DBOX_1	154:162	Mutation rewiring degron network	0.2778
p.P217L	TCGA-VQ-A8P2	STAD	TCGA	LKENR	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.1111
p.P217L	DO51761	STAD	ICGC	LKENR	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.1111
p.R171K	DO581	BLCA	ICGC	VRDDLKDVS	DEG_APCC_DBOX_1	154:162	Mutation rewiring degron network	0.0833
p.G172A	DO4942	BRCA	ICGC	VRDDLKDVS	DEG_APCC_DBOX_1	154:162	Mutation rewiring degron network	0.0556
p.S156F	DO6088	BRCA	ICGC	VRDDLKDVS	DEG_APCC_DBOX_1	154:162	Mutation altering degron motif	0.7982
p.I216V	DO6299	CESC	ICGC	LKENR	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.0833
p.N149I	DO233750	GACA	ICGC	VRDDLKDVS	DEG_APCC_DBOX_1	154:162	Mutation rewiring degron network	0.1944
p.P217T	DO228986	LICA	ICGC	LKENR	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.1111
p.E149K	DO26463	LUSC	ICGC	VRDDLKDVS	DEG_APCC_DBOX_1	154:162	Mutation rewiring degron network	0.1944
p.V159I	DO48174	UCEC	ICGC	VRDDLKDVS	DEG_APCC_DBOX_1	154:162	Mutation altering degron motif	0.7076
p.P228L	DO42416	UCEC	ICGC	LKENR	DEG_APCC_KENBOX_2	225:229	Mutation altering degron motif	0.7582
p.K218Q	SIDM01307	Colorectal Carcinoma	GDSC	LKENR	DEG_APCC_KENBOX_2	225:229	Mutation substituting flanking lysine	0.25
p.D157Y	SIDM00135	Breast Carcinoma	GDSC	VRDDLKDVS	DEG_APCC_DBOX_1	154:162	Mutation altering degron motif	0.6214
p.D157Y	SIDM01564	Colorectal Carcinoma	GDSC	VRDDLKDVS	DEG_APCC_DBOX_1	154:162	Mutation altering degron motif	0.6214
p.V169A	SIDM00499	Prostate Carcinoma	GDSC	VRDDLKDVS	DEG_APCC_DBOX_1	154:162	Mutation rewiring degron network	0.1389
p.V169A	ACH-000956	Prostate Cancer	CCLE	VRDDLKDVS	DEG_APCC_DBOX_1	154:162	Mutation rewiring degron network	0.1389
p.V169A	22RV1	prostate	COSMIC	VRDDLKDVS	DEG_APCC_DBOX_1	154:162	Mutation rewiring degron network	0.1389
p.S153G	SIDM00933	Breast Carcinoma	GDSC	VRDDLKDVS	DEG_APCC_DBOX_1	154:162	Mutation rewiring degron network	0.3056
p.S153G	ACH-000856	Breast Cancer	CCLE	VRDDLKDVS	DEG_APCC_DBOX_1	154:162	Mutation rewiring degron network	0.3056
p.S153G	CAL-51	breast	COSMIC	VRDDLKDVS	DEG_APCC_DBOX_1	154:162	Mutation rewiring degron network	0.3056
p.E146K	SIDM01040	Ovarian Carcinoma	GDSC	VRDDLKDVS	DEG_APCC_DBOX_1	154:162	Mutation rewiring degron network	0.1111
p.E146K	ACH-000574	Ovarian Cancer	CCLE	VRDDLKDVS	DEG_APCC_DBOX_1	154:162	Mutation rewiring degron network	0.1111
p.E146K	FU-OV-1	ovary	COSMIC	VRDDLKDVS	DEG_APCC_DBOX_1	154:162	Mutation rewiring degron network	0.1111
p.V169L	SIDM00426	Rhabdomyosarcoma	GDSC	VRDDLKDVS	DEG_APCC_DBOX_1	154:162	Mutation rewiring degron network	0.1389
p.V169L	ACH-000100	Sarcoma	CCLE	VRDDLKDVS	DEG_APCC_DBOX_1	154:162	Mutation rewiring degron network	0.1389
p.V169L	ACH-001765	Sarcoma	CCLE	VRDDLKDVS	DEG_APCC_DBOX_1	154:162	Mutation rewiring degron network	0.1389
p.V169L	RH-41	soft tissue	COSMIC	VRDDLKDVS	DEG_APCC_DBOX_1	154:162	Mutation rewiring degron network	0.1389
p.E231D	SIDM01218	Other Solid Cancers	GDSC	LKENR	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.2778
p.E231D	ACH-001530	Endometrial/Uterine Cancer	CCLE	LKENR	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.2778
p.E231D	JEG-3	placenta	COSMIC	LKENR	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.2778
p.P233L	SIDM01060	Melanoma	GDSC	LKENR	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.2222
p.P233L	ACH-000882	Skin Cancer	CCLE	LKENR	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.2222
p.P233L	IGR-1	skin	COSMIC	LKENR	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.2222
p.D224Y	SIDM00814	Other Solid Cancers	GDSC	LKENR	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.3056
p.D224Y	ACH-001401	Adrenal Cancer	CCLE	LKENR	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.3056
p.D224Y	SW13	adrenal gland	COSMIC	LKENR	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.3056
p.A148P	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	VRDDLKDVS	DEG_APCC_DBOX_1	154:162	Mutation rewiring degron network	0.1667
p.A148P	ACH-000875	Lung Cancer	CCLE	VRDDLKDVS	DEG_APCC_DBOX_1	154:162	Mutation rewiring degron network	0.1667
p.A148P	NCI-H2347	lung	COSMIC	VRDDLKDVS	DEG_APCC_DBOX_1	154:162	Mutation rewiring degron network	0.1667
p.S163G	A388	skin	COSMIC	VRDDLKDVS	DEG_APCC_DBOX_1	154:162	Mutation rewiring degron network	0.3056
p.S159F	KM12	large intestine	COSMIC	VRDDLKDVS	DEG_APCC_DBOX_1	154:162	Mutation altering degron motif	0.7982
p.P172L	SK-MEL-24	skin	COSMIC	VRDDLKDVS	DEG_APCC_DBOX_1	154:162	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZSCAN5A

UniProt ID: Q9BUG6

Entrez ID: 79149

Protein name: Zinc finger and SCAN domain-containing protein 5A (Zinc finger protein 495)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZSCAN5A in