DegronMD

Uniprot ID: Q9BUG6

Source protein: Zinc finger and SCAN domain-containing protein 5A

Source gene: ZSCAN5A

Class: DEG_APCC_KENBOX_2

Location: 225:229

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5671

ASA_SCORE: 110.86

COIL: 0.698

CONS_SCORE: 0.4171

DSS_SCORE: 0.7415

HELIX: 0.136

FCONS_SCORE: 0.7459

RIG_SCORE: 0.662

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E227K	TCGA-22-1000	LUSC	TCGA	LKENR	DEG_APCC_KENBOX_2	0.7022
p.E227K	TCGA-EE-A181	SKCM	TCGA	LKENR	DEG_APCC_KENBOX_2	0.7022
p.E227K	DO27060	LUSC	ICGC	LKENR	DEG_APCC_KENBOX_2	0.7022
p.E227K	DO37444	SKCM	ICGC	LKENR	DEG_APCC_KENBOX_2	0.7022
p.R216K	TCGA-22-1000	LUSC	TCGA	LKENR	DEG_APCC_KENBOX_2	0.0833
p.R216K	DO27060	LUSC	ICGC	LKENR	DEG_APCC_KENBOX_2	0.0833
p.E230K	TCGA-A2-A0EV	BRCA	TCGA	LKENR	DEG_APCC_KENBOX_2	0.3056
p.E230K	DO4942	BRCA	ICGC	LKENR	DEG_APCC_KENBOX_2	0.3056
p.E227V	TCGA-EE-A181	SKCM	TCGA	LKENR	DEG_APCC_KENBOX_2	0.7693
p.T236S	TCGA-F7-A622	HNSC	TCGA	LKENR	DEG_APCC_KENBOX_2	0.1389
p.T236S	DO49039	HNSC	ICGC	LKENR	DEG_APCC_KENBOX_2	0.1389
p.P217L	TCGA-VQ-A8P2	STAD	TCGA	LKENR	DEG_APCC_KENBOX_2	0.1111
p.P217L	DO51761	STAD	ICGC	LKENR	DEG_APCC_KENBOX_2	0.1111
p.I216V	DO6299	CESC	ICGC	LKENR	DEG_APCC_KENBOX_2	0.0833
p.P217T	DO228986	LICA	ICGC	LKENR	DEG_APCC_KENBOX_2	0.1111
p.P228L	DO42416	UCEC	ICGC	LKENR	DEG_APCC_KENBOX_2	0.7582
p.K218Q	SIDM01307	Colorectal Carcinoma	GDSC	LKENR	DEG_APCC_KENBOX_2	0.25
p.E231D	SIDM01218	Other Solid Cancers	GDSC	LKENR	DEG_APCC_KENBOX_2	0.2778
p.E231D	ACH-001530	Endometrial/Uterine Cancer	CCLE	LKENR	DEG_APCC_KENBOX_2	0.2778
p.E231D	JEG-3	placenta	COSMIC	LKENR	DEG_APCC_KENBOX_2	0.2778
p.P233L	SIDM01060	Melanoma	GDSC	LKENR	DEG_APCC_KENBOX_2	0.2222
p.P233L	ACH-000882	Skin Cancer	CCLE	LKENR	DEG_APCC_KENBOX_2	0.2222
p.P233L	IGR-1	skin	COSMIC	LKENR	DEG_APCC_KENBOX_2	0.2222
p.D224Y	SIDM00814	Other Solid Cancers	GDSC	LKENR	DEG_APCC_KENBOX_2	0.3056
p.D224Y	ACH-001401	Adrenal Cancer	CCLE	LKENR	DEG_APCC_KENBOX_2	0.3056
p.D224Y	SW13	adrenal_gland	COSMIC	LKENR	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96MY7	Protein FAM161B	DEG_APCC_KENBOX_2	518:522	LKENR	APC,CDC20,FZR1	0.9635	More...
Q9BUG6	Zinc finger and SCAN domain-containing protein 5A	DEG_APCC_KENBOX_2	225:229	LKENR	APC,CDC20,FZR1	0.5671	More...
Q8NA47	Coiled-coil domain-containing protein 63	DEG_APCC_KENBOX_2	535:539	LKENR	APC,CDC20,FZR1	0.5383	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LKENR

Degron related mutations and impact score

Drug responses associated with ZSCAN5A mutations

All proteins holding degron of LKENR