DegronMD

Uniprot ID: Q9BUG6

Source protein: Zinc finger and SCAN domain-containing protein 5A

Source gene: ZSCAN5A

Class: DEG_APCC_DBOX_1

Location: 154:162

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9409

ASA_SCORE: 85.0222

COIL: 0.6612

CONS_SCORE: 0.6191

DSS_SCORE: 0.5782

HELIX: 0.3003

FCONS_SCORE: 1.112

RIG_SCORE: 0.7117

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A148T	TCGA-A5-A0G2	UCEC	TCGA	VRDDLKDVS	DEG_APCC_DBOX_1	0.1667
p.A148T	DO41235	UCEC	ICGC	VRDDLKDVS	DEG_APCC_DBOX_1	0.1667
p.V161M	TCGA-AO-A128	BRCA	TCGA	VRDDLKDVS	DEG_APCC_DBOX_1	0.6097
p.V161M	DO5326	BRCA	ICGC	VRDDLKDVS	DEG_APCC_DBOX_1	0.6097
p.R155T	TCGA-E2-A152	BRCA	TCGA	VRDDLKDVS	DEG_APCC_DBOX_1	0.7876
p.S152C	TCGA-G6-A8L6	KIRC	TCGA	VRDDLKDVS	DEG_APCC_DBOX_1	0.2778
p.S152C	DO50649	KIRC	ICGC	VRDDLKDVS	DEG_APCC_DBOX_1	0.2778
p.R171K	DO581	BLCA	ICGC	VRDDLKDVS	DEG_APCC_DBOX_1	0.0833
p.G172A	DO4942	BRCA	ICGC	VRDDLKDVS	DEG_APCC_DBOX_1	0.0556
p.S156F	DO6088	BRCA	ICGC	VRDDLKDVS	DEG_APCC_DBOX_1	0.7982
p.N149I	DO233750	GACA	ICGC	VRDDLKDVS	DEG_APCC_DBOX_1	0.1944
p.E149K	DO26463	LUSC	ICGC	VRDDLKDVS	DEG_APCC_DBOX_1	0.1944
p.V159I	DO48174	UCEC	ICGC	VRDDLKDVS	DEG_APCC_DBOX_1	0.7076
p.D157Y	SIDM00135	Breast Carcinoma	GDSC	VRDDLKDVS	DEG_APCC_DBOX_1	0.6214
p.D157Y	SIDM01564	Colorectal Carcinoma	GDSC	VRDDLKDVS	DEG_APCC_DBOX_1	0.6214
p.V169A	SIDM00499	Prostate Carcinoma	GDSC	VRDDLKDVS	DEG_APCC_DBOX_1	0.1389
p.V169A	ACH-000956	Prostate Cancer	CCLE	VRDDLKDVS	DEG_APCC_DBOX_1	0.1389
p.V169A	22RV1	prostate	COSMIC	VRDDLKDVS	DEG_APCC_DBOX_1	0.1389
p.S153G	SIDM00933	Breast Carcinoma	GDSC	VRDDLKDVS	DEG_APCC_DBOX_1	0.3056
p.S153G	ACH-000856	Breast Cancer	CCLE	VRDDLKDVS	DEG_APCC_DBOX_1	0.3056
p.S153G	CAL-51	breast	COSMIC	VRDDLKDVS	DEG_APCC_DBOX_1	0.3056
p.E146K	SIDM01040	Ovarian Carcinoma	GDSC	VRDDLKDVS	DEG_APCC_DBOX_1	0.1111
p.E146K	ACH-000574	Ovarian Cancer	CCLE	VRDDLKDVS	DEG_APCC_DBOX_1	0.1111
p.E146K	FU-OV-1	ovary	COSMIC	VRDDLKDVS	DEG_APCC_DBOX_1	0.1111
p.V169L	SIDM00426	Rhabdomyosarcoma	GDSC	VRDDLKDVS	DEG_APCC_DBOX_1	0.1389
p.V169L	ACH-000100	Sarcoma	CCLE	VRDDLKDVS	DEG_APCC_DBOX_1	0.1389
p.V169L	ACH-001765	Sarcoma	CCLE	VRDDLKDVS	DEG_APCC_DBOX_1	0.1389
p.V169L	RH-41	soft_tissue	COSMIC	VRDDLKDVS	DEG_APCC_DBOX_1	0.1389
p.A148P	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	VRDDLKDVS	DEG_APCC_DBOX_1	0.1667
p.A148P	ACH-000875	Lung Cancer	CCLE	VRDDLKDVS	DEG_APCC_DBOX_1	0.1667
p.A148P	NCI-H2347	lung	COSMIC	VRDDLKDVS	DEG_APCC_DBOX_1	0.1667
p.S163G	A388	skin	COSMIC	VRDDLKDVS	DEG_APCC_DBOX_1	0.3056
p.S159F	KM12	large_intestine	COSMIC	VRDDLKDVS	DEG_APCC_DBOX_1	0.7982
p.P172L	SK-MEL-24	skin	COSMIC	VRDDLKDVS	DEG_APCC_DBOX_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VRDDLKDVS

Degron related mutations and impact score

Drug responses associated with ZSCAN5A mutations

All proteins holding degron of VRDDLKDVS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BUG6	Zinc finger and SCAN domain-containing protein 5A	DEG_APCC_DBOX_1	154:162	VRDDLKDVS	APC,CDC20,FZR1	0.9409	More...