DegronMD

Uniprot ID: Q99805

Source protein: Transmembrane 9 superfamily member 2

Source gene: TM9SF2

Class: DEG_APCC_DBOX_1

Location: 14:22

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9137

ASA_SCORE: 74.8444

COIL: 0.1443

CONS_SCORE: 0.401

DSS_SCORE: 0.0171

HELIX: 0.8426

FCONS_SCORE: 1.8056

RIG_SCORE: 0.9158

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S9Y	TCGA-BK-A6W3	UCEC	TCGA	PRLLLLSLL	DEG_APCC_DBOX_1	0.1944
p.S9Y	DO50076	UCEC	ICGC	PRLLLLSLL	DEG_APCC_DBOX_1	0.1944
p.R31H	TCGA-TS-A8AI	MESO	TCGA	PRLLLLSLL	DEG_APCC_DBOX_1	0.0833
p.S20L	DO50410	ESAD	ICGC	PRLLLLSLL	DEG_APCC_DBOX_1	0.7667
p.L17S	DO44664	LICA	ICGC	PRLLLLSLL	DEG_APCC_DBOX_1	0.6556
p.V7M	SIDM01609	Endometrial Carcinoma	GDSC	PRLLLLSLL	DEG_APCC_DBOX_1	0.1389
p.V7M	ACH-000972	Endometrial/Uterine Cancer	CCLE	PRLLLLSLL	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99805	Transmembrane 9 superfamily member 2	DEG_APCC_DBOX_1	14:22	PRLLLLSLL	APC,CDC20,FZR1	0.9137	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons