DegronMD

Uniprot ID: A6NJJ6

Source protein: UPF0575 protein C19orf67

Source gene: C19orf67

Class: DEG_APCC_DBOX_1

Location: 80:88

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6482

ASA_SCORE: 76.8556

COIL: 0.4429

CONS_SCORE: 0.8857

DSS_SCORE: 0.4681

HELIX: 0.5134

FCONS_SCORE: 1.1008

RIG_SCORE: 0.7381

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R96C	DO220484	KICH	ICGC	PRLSLDTLF	DEG_APCC_DBOX_1	0.1111
p.S83Y	DO228952	LICA	ICGC	PRLSLDTLF	DEG_APCC_DBOX_1	0.6009
p.S83Y	DO229006	LICA	ICGC	PRLSLDTLF	DEG_APCC_DBOX_1	0.6009
p.D85E	DO229019	LICA	ICGC	PRLSLDTLF	DEG_APCC_DBOX_1	0.5647
p.A78E	DO229036	LICA	ICGC	PRLSLDTLF	DEG_APCC_DBOX_1	0.2778
p.Q94K	DO229038	LICA	ICGC	PRLSLDTLF	DEG_APCC_DBOX_1	0.1667
p.L82I	DO229045	LICA	ICGC	PRLSLDTLF	DEG_APCC_DBOX_1	0.6063
p.V72A	DO38404	STAD	ICGC	PRLSLDTLF	DEG_APCC_DBOX_1	0.1111
p.R81H	SIDM02050	Colorectal Carcinoma	GDSC	PRLSLDTLF	DEG_APCC_DBOX_1	0.8244

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NJJ6	UPF0575 protein C19orf67	DEG_APCC_DBOX_1	80:88	PRLSLDTLF	APC,CDC20,FZR1	0.6482	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons