DegronMD

Uniprot ID: Q9NPR2

Source protein: Semaphorin-4B

Source gene: SEMA4B

Class: DEG_APCC_DBOX_1

Location: 21:29

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6339

ASA_SCORE: 82.8444

COIL: 0.4437

CONS_SCORE: 0.5099

DSS_SCORE: 0.0055

HELIX: 0.5269

FCONS_SCORE: 1.4534

RIG_SCORE: 0.9044

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A14S	DO229029	LICA	ICGC	PRPPLLLLL	DEG_APCC_DBOX_1	0.1389
p.W16C	DO27827	MALY	ICGC	PRPPLLLLL	DEG_APCC_DBOX_1	0.1944
p.L33F	ACH-000555	Kidney Cancer	CCLE	PRPPLLLLL	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NPR2	Semaphorin-4B	DEG_APCC_DBOX_1	21:29	PRPPLLLLL	APC,CDC20,FZR1	0.6339	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons