DegronMD - Q9NPR2(SEMA4B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H389N	TCGA-5M-AAT6	COAD	TCGA	TVTHPVPTP	DEG_COP1_1	386:394	Mutation altering degron motif	0.6312
p.H389N	DO223703	COAD	ICGC	TVTHPVPTP	DEG_COP1_1	386:394	Mutation altering degron motif	0.6312
p.Y385H	TCGA-B5-A1MX	UCEC	TCGA	TVTHPVPTP	DEG_COP1_1	386:394	Mutation rewiring degron network	0.3056
p.Y385H	DO41999	UCEC	ICGC	TVTHPVPTP	DEG_COP1_1	386:394	Mutation rewiring degron network	0.3056
p.W384L	TCGA-EE-A2MK	SKCM	TCGA	TVTHPVPTP	DEG_COP1_1	386:394	Mutation rewiring degron network	0.2778
p.W384L	DO38177	SKCM	ICGC	TVTHPVPTP	DEG_COP1_1	386:394	Mutation rewiring degron network	0.2778
p.R379S	TCGA-FS-A1ZB	SKCM	TCGA	TVTHPVPTP	DEG_COP1_1	386:394	Mutation rewiring degron network	0.1389
p.R379S	DO37886	SKCM	ICGC	TVTHPVPTP	DEG_COP1_1	386:394	Mutation rewiring degron network	0.1389
p.R395Q	DO230342	COCA	ICGC	TVTHPVPTP	DEG_COP1_1	386:394	Mutation rewiring degron network	0.3056
p.A14S	DO229029	LICA	ICGC	PRPPLLLLL	DEG_APCC_DBOX_1	21:29	Mutation rewiring degron network	0.1389
p.W16C	DO27827	MALY	ICGC	PRPPLLLLL	DEG_APCC_DBOX_1	21:29	Mutation rewiring degron network	0.1944
p.A398T	DO50698	ORCA	ICGC	TVTHPVPTP	DEG_COP1_1	386:394	Mutation rewiring degron network	0.2222
p.P387L	DO229502	SKCA	ICGC	TVTHPVPTP	DEG_COP1_1	386:394	Mutation altering degron motif	0.7582
p.A398V	SIDM00310	Mesothelioma	GDSC	TVTHPVPTP	DEG_COP1_1	386:394	Mutation rewiring degron network	0.2222
p.A398V	H2804	pleura	COSMIC	TVTHPVPTP	DEG_COP1_1	386:394	Mutation rewiring degron network	0.2222
p.R395W	SIDM00537	Colorectal Carcinoma	GDSC	TVTHPVPTP	DEG_COP1_1	386:394	Mutation rewiring degron network	0.3056
p.R395W	ACH-000982	Colon/Colorectal Cancer	CCLE	TVTHPVPTP	DEG_COP1_1	386:394	Mutation rewiring degron network	0.3056
p.R395W	ACH-001345	Colon/Colorectal Cancer	CCLE	TVTHPVPTP	DEG_COP1_1	386:394	Mutation rewiring degron network	0.3056
p.R395W	GP5d	large intestine	COSMIC	TVTHPVPTP	DEG_COP1_1	386:394	Mutation rewiring degron network	0.3056
p.L33F	ACH-000555	Kidney Cancer	CCLE	PRPPLLLLL	DEG_APCC_DBOX_1	21:29	Mutation rewiring degron network	0.2222

Kaplan plot for SEMA4B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SEMA4B

UniProt ID: Q9NPR2

Entrez ID: 10509

Protein name: Semaphorin-4B (Semaphorin-C)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SEMA4B in