DegronMD

Uniprot ID: Q9NPR2

Source protein: Semaphorin-4B

Source gene: SEMA4B

Class: DEG_COP1_1

Location: 386:394

E3 ligase: COP1

DEGRON score: 0.9542

ASA_SCORE: 83.4

COIL: 0.8671

CONS_SCORE: 0.6011

DSS_SCORE: 0.4697

HELIX: 0.0124

FCONS_SCORE: 1.4357

RIG_SCORE: 0.7658

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H389N	TCGA-5M-AAT6	COAD	TCGA	TVTHPVPTP	DEG_COP1_1	0.6312
p.H389N	DO223703	COAD	ICGC	TVTHPVPTP	DEG_COP1_1	0.6312
p.Y385H	TCGA-B5-A1MX	UCEC	TCGA	TVTHPVPTP	DEG_COP1_1	0.3056
p.Y385H	DO41999	UCEC	ICGC	TVTHPVPTP	DEG_COP1_1	0.3056
p.W384L	TCGA-EE-A2MK	SKCM	TCGA	TVTHPVPTP	DEG_COP1_1	0.2778
p.W384L	DO38177	SKCM	ICGC	TVTHPVPTP	DEG_COP1_1	0.2778
p.R379S	TCGA-FS-A1ZB	SKCM	TCGA	TVTHPVPTP	DEG_COP1_1	0.1389
p.R379S	DO37886	SKCM	ICGC	TVTHPVPTP	DEG_COP1_1	0.1389
p.R395Q	DO230342	COCA	ICGC	TVTHPVPTP	DEG_COP1_1	0.3056
p.A398T	DO50698	ORCA	ICGC	TVTHPVPTP	DEG_COP1_1	0.2222
p.P387L	DO229502	SKCA	ICGC	TVTHPVPTP	DEG_COP1_1	0.7582
p.A398V	SIDM00310	Mesothelioma	GDSC	TVTHPVPTP	DEG_COP1_1	0.2222
p.A398V	H2804	pleura	COSMIC	TVTHPVPTP	DEG_COP1_1	0.2222
p.R395W	SIDM00537	Colorectal Carcinoma	GDSC	TVTHPVPTP	DEG_COP1_1	0.3056
p.R395W	ACH-000982	Colon/Colorectal Cancer	CCLE	TVTHPVPTP	DEG_COP1_1	0.3056
p.R395W	ACH-001345	Colon/Colorectal Cancer	CCLE	TVTHPVPTP	DEG_COP1_1	0.3056
p.R395W	GP5d	large_intestine	COSMIC	TVTHPVPTP	DEG_COP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NPR2	Semaphorin-4B	DEG_COP1_1	386:394	TVTHPVPTP	COP1	0.9542	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons