DegronMD

Uniprot ID: Q6ZR37

Source protein: Pleckstrin homology domain-containing family G member 7

Source gene: PLEKHG7

Class: DEG_APCC_DBOX_1

Location: 20:28

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9317

ASA_SCORE: 86.0222

COIL: 0.8713

CONS_SCORE: 0.6623

DSS_SCORE: 0.6658

HELIX: 0.069

FCONS_SCORE: 1.1409

RIG_SCORE: 0.647

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E14K	TCGA-C8-A26Y	BRCA	TCGA	PRPSLRSLP	DEG_APCC_DBOX_1	0.1667
p.E14K	DO1273	BRCA	ICGC	PRPSLRSLP	DEG_APCC_DBOX_1	0.1667
p.L36F	TCGA-E2-A1B5	BRCA	TCGA	PRPSLRSLP	DEG_APCC_DBOX_1	0.1111
p.L36F	DO3299	BRCA	ICGC	PRPSLRSLP	DEG_APCC_DBOX_1	0.1111
p.L16I	TCGA-F5-6814	READ	TCGA	PRPSLRSLP	DEG_APCC_DBOX_1	0.2222
p.L16I	DO36556	READ	ICGC	PRPSLRSLP	DEG_APCC_DBOX_1	0.2222
p.L16F	TCGA-FW-A3R5	SKCM	TCGA	PRPSLRSLP	DEG_APCC_DBOX_1	0.2222
p.L16F	DO37406	SKCM	ICGC	PRPSLRSLP	DEG_APCC_DBOX_1	0.2222
p.A26G	DO223048	ESCA	ICGC	PRPSLRSLP	DEG_APCC_DBOX_1	0.754
p.L31V	DO233030	GACA	ICGC	PRPSLRSLP	DEG_APCC_DBOX_1	0.25
p.D18Y	DO225400	LAML	ICGC	PRPSLRSLP	DEG_APCC_DBOX_1	0.2778
p.Q11H	ACH-001991	Primary	CCLE	PRPSLRSLP	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZR37	Pleckstrin homology domain-containing family G member 7	DEG_APCC_DBOX_1	20:28	PRPSLRSLP	APC,CDC20,FZR1	0.9317	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons