DegronMD

Uniprot ID: Q96AX9

Source protein: E3 ubiquitin-protein ligase MIB2

Source gene: MIB2

Class: DEG_APCC_DBOX_1

Location: 145:153

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6939

ASA_SCORE: 66.7222

COIL: 0.6866

CONS_SCORE: 0.682

DSS_SCORE: 0.4519

HELIX: 0.0877

FCONS_SCORE: 0.9287

RIG_SCORE: 0.7428

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G139D	TCGA-D1-A17D	UCEC	TCGA	PRQGLPRIP	DEG_APCC_DBOX_1	0.1667
p.P145R	DO228404	BRCA	ICGC	PRQGLPRIP	DEG_APCC_DBOX_1	0.6401
p.Q139K	ACH-000934	Breast Cancer	CCLE	PRQGLPRIP	DEG_APCC_DBOX_1	0.1667
p.A141T	SNU-1040	large_intestine	COSMIC	PRQGLPRIP	DEG_APCC_DBOX_1	0.2222
p.A141T	MEG-01	haematopoietic_and_lymphoid_tissue	COSMIC	PRQGLPRIP	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96AX9	E3 ubiquitin-protein ligase MIB2	DEG_APCC_DBOX_1	145:153	PRQGLPRIP	APC,CDC20,FZR1	0.6939	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons