DegronMD - Q96AX9(MIB2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G139D	TCGA-D1-A17D	UCEC	TCGA	PRQGLPRIP	DEG_APCC_DBOX_1	145:153	Mutation rewiring degron network	0.1667
p.P145R	DO228404	BRCA	ICGC	PRQGLPRIP	DEG_APCC_DBOX_1	145:153	Mutation altering degron motif	0.6401
p.M45T	DO229010	COCA	ICGC	PSTPDRT	DEG_SCF_FBW7_1	45:51	Mutation altering degron motif	0.7423
p.M45T	DO229013	COCA	ICGC	PSTPDRT	DEG_SCF_FBW7_1	45:51	Mutation altering degron motif	0.7423
p.M45T	DO229016	COCA	ICGC	PSTPDRT	DEG_SCF_FBW7_1	45:51	Mutation altering degron motif	0.7423
p.M45T	DO229003	COCA	ICGC	PSTPDRT	DEG_SCF_FBW7_1	45:51	Mutation altering degron motif	0.7423
p.M45T	DO230993	LUSC	ICGC	PSTPDRT	DEG_SCF_FBW7_1	45:51	Mutation altering degron motif	0.7423
p.P56L	DO233913	GACA	ICGC	PSTPDRT	DEG_SCF_FBW7_1	45:51	Mutation rewiring degron network	0.1944
p.A44S	DO228978	LICA	ICGC	PSTPDRT	DEG_SCF_FBW7_1	45:51	Mutation rewiring degron network	0.3056
p.A40S	DO229037	LICA	ICGC	PSTPDRT	DEG_SCF_FBW7_1	45:51	Mutation rewiring degron network	0.1944
p.M45I	DO229037	LICA	ICGC	PSTPDRT	DEG_SCF_FBW7_1	45:51	Mutation altering degron motif	0.7618
p.P43A	DO219578	LIHC	ICGC	PSTPDRT	DEG_SCF_FBW7_1	45:51	Mutation rewiring degron network	0.2778
p.D46Y	DO25189	LUAD	ICGC	PSTPDRT	DEG_SCF_FBW7_1	45:51	Mutation altering degron motif	0.7325
p.A54E	DO33432	PACA	ICGC	PSTPDRT	DEG_SCF_FBW7_1	45:51	Mutation rewiring degron network	0.25
p.P56Q	DO232675	PBCA	ICGC	PSTPDRT	DEG_SCF_FBW7_1	45:51	Mutation rewiring degron network	0.1944
p.P47S	DO37418	SKCM	ICGC	PSTPDRT	DEG_SCF_FBW7_1	45:51	Mutation altering degron motif	0.6752
p.S48F	DO51254	SKCM	ICGC	PSTPDRT	DEG_SCF_FBW7_1	45:51	Mutation altering degron motif	0.7982
p.G36E	ACH-000929	Lung Cancer	CCLE	PSTPDRT	DEG_SCF_FBW7_1	45:51	Mutation rewiring degron network	0.0833
p.Q139K	ACH-000934	Breast Cancer	CCLE	PRQGLPRIP	DEG_APCC_DBOX_1	145:153	Mutation rewiring degron network	0.1667
p.A141T	SNU-1040	large intestine	COSMIC	PRQGLPRIP	DEG_APCC_DBOX_1	145:153	Mutation rewiring degron network	0.2222
p.A141T	MEG-01	haematopoietic and lymphoid tissue	COSMIC	PRQGLPRIP	DEG_APCC_DBOX_1	145:153	Mutation rewiring degron network	0.2222

Kaplan plot for MIB2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MIB2

UniProt ID: Q96AX9

Entrez ID: 142678

Protein name: E3 ubiquitin-protein ligase MIB2 (EC 2.3.2.27) (Mind bomb homolog 2) (Novel zinc finger protein) (Novelzin) (Putative NF-kappa-B-activating protein 002N) (RING-type E3 ubiquitin transferase MIB2) (Skeletrophin) (Zinc finger ZZ type with ankyrin repeat domain protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MIB2 in