DegronMD

Uniprot ID: Q96AX9

Source protein: E3 ubiquitin-protein ligase MIB2

Source gene: MIB2

Class: DEG_SCF_FBW7_1

Location: 45:51

E3 ligase: FBXW7

DEGRON score: 0.6521

ASA_SCORE: 72.4571

COIL: 0.805

CONS_SCORE: 0.206

DSS_SCORE: 0.5366

HELIX: 0.0451

FCONS_SCORE: 1.0837

RIG_SCORE: 0.6888

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M45T	DO229010	COCA	ICGC	PSTPDRT	DEG_SCF_FBW7_1	0.7423
p.M45T	DO229013	COCA	ICGC	PSTPDRT	DEG_SCF_FBW7_1	0.7423
p.M45T	DO229016	COCA	ICGC	PSTPDRT	DEG_SCF_FBW7_1	0.7423
p.M45T	DO229003	COCA	ICGC	PSTPDRT	DEG_SCF_FBW7_1	0.7423
p.M45T	DO230993	LUSC	ICGC	PSTPDRT	DEG_SCF_FBW7_1	0.7423
p.P56L	DO233913	GACA	ICGC	PSTPDRT	DEG_SCF_FBW7_1	0.1944
p.A44S	DO228978	LICA	ICGC	PSTPDRT	DEG_SCF_FBW7_1	0.3056
p.A40S	DO229037	LICA	ICGC	PSTPDRT	DEG_SCF_FBW7_1	0.1944
p.M45I	DO229037	LICA	ICGC	PSTPDRT	DEG_SCF_FBW7_1	0.7618
p.P43A	DO219578	LIHC	ICGC	PSTPDRT	DEG_SCF_FBW7_1	0.2778
p.D46Y	DO25189	LUAD	ICGC	PSTPDRT	DEG_SCF_FBW7_1	0.7325
p.A54E	DO33432	PACA	ICGC	PSTPDRT	DEG_SCF_FBW7_1	0.25
p.P56Q	DO232675	PBCA	ICGC	PSTPDRT	DEG_SCF_FBW7_1	0.1944
p.P47S	DO37418	SKCM	ICGC	PSTPDRT	DEG_SCF_FBW7_1	0.6752
p.S48F	DO51254	SKCM	ICGC	PSTPDRT	DEG_SCF_FBW7_1	0.7982
p.G36E	ACH-000929	Lung Cancer	CCLE	PSTPDRT	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96AX9	E3 ubiquitin-protein ligase MIB2	DEG_SCF_FBW7_1	45:51	PSTPDRT	FBXW7	0.6521	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons