DegronMD

Uniprot ID: P15918

Source protein: V

Source gene: RAG1

Class: DEG_APCC_DBOX_1

Location: 395:403

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8892

ASA_SCORE: 82.9111

COIL: 0.4311

CONS_SCORE: 0.7704

DSS_SCORE: 0.5395

HELIX: 0.4119

FCONS_SCORE: 1.1907

RIG_SCORE: 0.7584

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G392V	TCGA-06-2569	GBM	TCGA	PRQHLLSLT	DEG_APCC_DBOX_1	0.25
p.G392V	DO12202	GBM	ICGC	PRQHLLSLT	DEG_APCC_DBOX_1	0.25
p.L402P	TCGA-AD-6889	COAD	TCGA	PRQHLLSLT	DEG_APCC_DBOX_1	0.7582
p.L402P	DO8463	COAD	ICGC	PRQHLLSLT	DEG_APCC_DBOX_1	0.7582
p.R410W	TCGA-BR-4370	STAD	TCGA	PRQHLLSLT	DEG_APCC_DBOX_1	0.1389
p.R410W	DO38499	STAD	ICGC	PRQHLLSLT	DEG_APCC_DBOX_1	0.1389
p.R396C	TCGA-CN-4741	HNSC	TCGA	PRQHLLSLT	DEG_APCC_DBOX_1	0.8301
p.R396C	TCGA-XP-A8T6	ESCA	TCGA	PRQHLLSLT	DEG_APCC_DBOX_1	0.8301
p.R396C	DO233254	GACA	ICGC	PRQHLLSLT	DEG_APCC_DBOX_1	0.8301
p.R396C	DO14313	HNSC	ICGC	PRQHLLSLT	DEG_APCC_DBOX_1	0.8301
p.S401L	TCGA-WE-A8K4	SKCM	TCGA	PRQHLLSLT	DEG_APCC_DBOX_1	0.6556
p.S401L	DO222880	MELA	ICGC	PRQHLLSLT	DEG_APCC_DBOX_1	0.6556
p.S401L	DO229586	PRAD	ICGC	PRQHLLSLT	DEG_APCC_DBOX_1	0.6556
p.S401L	DO51281	SKCM	ICGC	PRQHLLSLT	DEG_APCC_DBOX_1	0.6556
p.R410Q	DO233132	GACA	ICGC	PRQHLLSLT	DEG_APCC_DBOX_1	0.1389
p.R405S	SIDM00545	Melanoma	GDSC	PRQHLLSLT	DEG_APCC_DBOX_1	0.2778
p.R405S	ACH-000987	Skin Cancer	CCLE	PRQHLLSLT	DEG_APCC_DBOX_1	0.2778
p.R405S	Mewo	skin	COSMIC	PRQHLLSLT	DEG_APCC_DBOX_1	0.2778
p.R396H	SIDM01622	Breast Carcinoma	GDSC	PRQHLLSLT	DEG_APCC_DBOX_1	0.8244
p.R396H	ACH-000721	Breast Cancer	CCLE	PRQHLLSLT	DEG_APCC_DBOX_1	0.8244
p.R412T	SIDM01471	Chronic Myelogenous Leukemia	GDSC	PRQHLLSLT	DEG_APCC_DBOX_1	0.0833
p.R412T	ACH-000604	Leukemia	CCLE	PRQHLLSLT	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15918	V	DEG_APCC_DBOX_1	395:403	PRQHLLSLT	APC,CDC20,FZR1	0.8892	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons