DegronMD

Uniprot ID: Q5SY16

Source protein: Polynucleotide 5'-hydroxyl-kinase NOL9

Source gene: NOL9

Class: DEG_APCC_DBOX_1

Location: 33:41

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5207

ASA_SCORE: 115.2556

COIL: 0.7193

CONS_SCORE: 0.248

DSS_SCORE: 0.2009

HELIX: 0.2682

FCONS_SCORE: 1.0598

RIG_SCORE: 0.7844

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W50R	DO229010	COCA	ICGC	PRRRLGSLR	DEG_APCC_DBOX_1	0.0833
p.W50R	DO229013	COCA	ICGC	PRRRLGSLR	DEG_APCC_DBOX_1	0.0833
p.W50R	DO229016	COCA	ICGC	PRRRLGSLR	DEG_APCC_DBOX_1	0.0833
p.W50R	DO229003	COCA	ICGC	PRRRLGSLR	DEG_APCC_DBOX_1	0.0833
p.W50R	DO229005	COCA	ICGC	PRRRLGSLR	DEG_APCC_DBOX_1	0.0833
p.L29V	DO27801	MALY	ICGC	PRRRLGSLR	DEG_APCC_DBOX_1	0.2222
p.L29I	DO52675	MALY	ICGC	PRRRLGSLR	DEG_APCC_DBOX_1	0.2222
p.S30R	DO52663	MALY	ICGC	PRRRLGSLR	DEG_APCC_DBOX_1	0.25
p.P33S	DO228414	MALY	ICGC	PRRRLGSLR	DEG_APCC_DBOX_1	0.5641
p.C43S	DO228429	MALY	ICGC	PRRRLGSLR	DEG_APCC_DBOX_1	0.2778
p.L27F	DO228429	MALY	ICGC	PRRRLGSLR	DEG_APCC_DBOX_1	0.1667
p.A23S	SIDM01649	Non-Cancerous	GDSC	PRRRLGSLR	DEG_APCC_DBOX_1	0.0556
p.P25S	SIDM00889	Cervical Carcinoma	GDSC	PRRRLGSLR	DEG_APCC_DBOX_1	0.1111
p.P25S	ACH-001333	Cervical Cancer	CCLE	PRRRLGSLR	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5SY16	Polynucleotide 5'-hydroxyl-kinase NOL9	DEG_APCC_DBOX_1	33:41	PRRRLGSLR	APC,CDC20,FZR1	0.5207	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons