DegronMD - Q5SY16(NOL9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P78R	DO225009	BRCA	ICGC	PSPTPASE	DEG_SCF_FBW7_2	87:94	Mutation rewiring degron network	0.0833
p.P78R	DO52556	BRCA	ICGC	PSPTPASE	DEG_SCF_FBW7_2	87:94	Mutation rewiring degron network	0.0833
p.W50R	DO229010	COCA	ICGC	PRRRLGSLR	DEG_APCC_DBOX_1	33:41	Mutation rewiring degron network	0.0833
p.W50R	DO229013	COCA	ICGC	PRRRLGSLR	DEG_APCC_DBOX_1	33:41	Mutation rewiring degron network	0.0833
p.W50R	DO229016	COCA	ICGC	PRRRLGSLR	DEG_APCC_DBOX_1	33:41	Mutation rewiring degron network	0.0833
p.W50R	DO229003	COCA	ICGC	PRRRLGSLR	DEG_APCC_DBOX_1	33:41	Mutation rewiring degron network	0.0833
p.W50R	DO229005	COCA	ICGC	PRRRLGSLR	DEG_APCC_DBOX_1	33:41	Mutation rewiring degron network	0.0833
p.A104V	DO50372	ESAD	ICGC	PSPTPASE	DEG_SCF_FBW7_2	87:94	Mutation rewiring degron network	0.0556
p.P95S	DO27811	MALY	ICGC	PSPTPASE	DEG_SCF_FBW7_2	87:94	Mutation rewiring degron network	0.3056
p.P95S	DO228414	MALY	ICGC	PSPTPASE	DEG_SCF_FBW7_2	87:94	Mutation rewiring degron network	0.3056
p.L29V	DO27801	MALY	ICGC	PRRRLGSLR	DEG_APCC_DBOX_1	33:41	Mutation rewiring degron network	0.2222
p.T80I	DO52672	MALY	ICGC	PSPTPASE	DEG_SCF_FBW7_2	87:94	Mutation rewiring degron network	0.1389
p.T80I	DO228414	MALY	ICGC	PSPTPASE	DEG_SCF_FBW7_2	87:94	Mutation rewiring degron network	0.1389
p.L29I	DO52675	MALY	ICGC	PRRRLGSLR	DEG_APCC_DBOX_1	33:41	Mutation rewiring degron network	0.2222
p.E98K	DO52663	MALY	ICGC	PSPTPASE	DEG_SCF_FBW7_2	87:94	Mutation rewiring degron network	0.2222
p.S30R	DO52663	MALY	ICGC	PRRRLGSLR	DEG_APCC_DBOX_1	33:41	Mutation rewiring degron network	0.25
p.L101F	DO228305	MALY	ICGC	PSPTPASE	DEG_SCF_FBW7_2	87:94	Mutation rewiring degron network	0.1389
p.L101F	DO228414	MALY	ICGC	PSPTPASE	DEG_SCF_FBW7_2	87:94	Mutation rewiring degron network	0.1389
p.P78L	DO228414	MALY	ICGC	PSPTPASE	DEG_SCF_FBW7_2	87:94	Mutation rewiring degron network	0.0833
p.P33S	DO228414	MALY	ICGC	PRRRLGSLR	DEG_APCC_DBOX_1	33:41	Mutation altering degron motif	0.5641
p.C43S	DO228429	MALY	ICGC	PRRRLGSLR	DEG_APCC_DBOX_1	33:41	Mutation rewiring degron network	0.2778
p.L27F	DO228429	MALY	ICGC	PRRRLGSLR	DEG_APCC_DBOX_1	33:41	Mutation rewiring degron network	0.1667
p.P99L	DO220893	MELA	ICGC	PSPTPASE	DEG_SCF_FBW7_2	87:94	Mutation rewiring degron network	0.1944
p.P87L	DO220899	MELA	ICGC	PSPTPASE	DEG_SCF_FBW7_2	87:94	Mutation altering degron motif	0.6471
p.P95T	DO229272	THCA	ICGC	PSPTPASE	DEG_SCF_FBW7_2	87:94	Mutation rewiring degron network	0.3056
p.A23S	SIDM01649	Non-Cancerous	GDSC	PRRRLGSLR	DEG_APCC_DBOX_1	33:41	Mutation rewiring degron network	0.0556
p.P25S	SIDM00889	Cervical Carcinoma	GDSC	PRRRLGSLR	DEG_APCC_DBOX_1	33:41	Mutation rewiring degron network	0.1111
p.P25S	ACH-001333	Cervical Cancer	CCLE	PRRRLGSLR	DEG_APCC_DBOX_1	33:41	Mutation rewiring degron network	0.1111
p.E94G	ACH-000800	Lung Cancer	CCLE	PSPTPASE	DEG_SCF_FBW7_2	87:94	Mutation altering degron motif	0.7199
p.L101I	ACH-001274	Sarcoma	CCLE	PSPTPASE	DEG_SCF_FBW7_2	87:94	Mutation rewiring degron network	0.1389
p.P87S	ACH-001569	Skin Cancer	CCLE	PSPTPASE	DEG_SCF_FBW7_2	87:94	Mutation altering degron motif	0.6752
p.T82N	ACH-001982	Metastasis	CCLE	PSPTPASE	DEG_SCF_FBW7_2	87:94	Mutation rewiring degron network	0.1944

Kaplan plot for NOL9 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NOL9

UniProt ID: Q5SY16

Entrez ID: 79707

Protein name: Polynucleotide 5'-hydroxyl-kinase NOL9 (EC 2.7.1.-) (Nucleolar protein 9)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NOL9 in