DegronMD

Uniprot ID: Q5SY16

Source protein: Polynucleotide 5'-hydroxyl-kinase NOL9

Source gene: NOL9

Class: DEG_SCF_FBW7_2

Location: 87:94

E3 ligase: FBXW7

DEGRON score: 0.6307

ASA_SCORE: 94.5

COIL: 0.9663

CONS_SCORE: 0.2307

DSS_SCORE: 0.8043

HELIX: 0.0169

FCONS_SCORE: 1.0125

RIG_SCORE: 0.5029

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P78R	DO225009	BRCA	ICGC	PSPTPASE	DEG_SCF_FBW7_2	0.0833
p.P78R	DO52556	BRCA	ICGC	PSPTPASE	DEG_SCF_FBW7_2	0.0833
p.A104V	DO50372	ESAD	ICGC	PSPTPASE	DEG_SCF_FBW7_2	0.0556
p.P95S	DO27811	MALY	ICGC	PSPTPASE	DEG_SCF_FBW7_2	0.3056
p.P95S	DO228414	MALY	ICGC	PSPTPASE	DEG_SCF_FBW7_2	0.3056
p.T80I	DO52672	MALY	ICGC	PSPTPASE	DEG_SCF_FBW7_2	0.1389
p.T80I	DO228414	MALY	ICGC	PSPTPASE	DEG_SCF_FBW7_2	0.1389
p.E98K	DO52663	MALY	ICGC	PSPTPASE	DEG_SCF_FBW7_2	0.2222
p.L101F	DO228305	MALY	ICGC	PSPTPASE	DEG_SCF_FBW7_2	0.1389
p.L101F	DO228414	MALY	ICGC	PSPTPASE	DEG_SCF_FBW7_2	0.1389
p.P78L	DO228414	MALY	ICGC	PSPTPASE	DEG_SCF_FBW7_2	0.0833
p.P99L	DO220893	MELA	ICGC	PSPTPASE	DEG_SCF_FBW7_2	0.1944
p.P87L	DO220899	MELA	ICGC	PSPTPASE	DEG_SCF_FBW7_2	0.6471
p.P95T	DO229272	THCA	ICGC	PSPTPASE	DEG_SCF_FBW7_2	0.3056
p.E94G	ACH-000800	Lung Cancer	CCLE	PSPTPASE	DEG_SCF_FBW7_2	0.7199
p.L101I	ACH-001274	Sarcoma	CCLE	PSPTPASE	DEG_SCF_FBW7_2	0.1389
p.P87S	ACH-001569	Skin Cancer	CCLE	PSPTPASE	DEG_SCF_FBW7_2	0.6752
p.T82N	ACH-001982	Metastasis	CCLE	PSPTPASE	DEG_SCF_FBW7_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5SY16	Polynucleotide 5'-hydroxyl-kinase NOL9	DEG_SCF_FBW7_2	87:94	PSPTPASE	FBXW7	0.6307	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons