DegronMD

Uniprot ID: Q6UY14

Source protein: ADAMTS-like protein 4

Source gene: ADAMTSL4

Class: DEG_APCC_DBOX_1

Location: 179:187

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9143

ASA_SCORE: 89.0556

COIL: 0.7437

CONS_SCORE: 0.2895

DSS_SCORE: 0.6749

HELIX: 0.2198

FCONS_SCORE: 1.0146

RIG_SCORE: 0.6289

Show entries

Search:

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R180I	TCGA-EO-A22U	UCEC	TCGA	PRSELSLIS	DEG_APCC_DBOX_1	0.8102
p.R180I	DO43755	UCEC	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	0.8102
p.S177T	TCGA-YD-A89C	SKCM	TCGA	PRSELSLIS	DEG_APCC_DBOX_1	0.7222
p.S177T	DO219501	SKCM	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	0.7222
p.S177I	DO229028	LICA	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	0.7222
p.L183M	DO232761	PBCA	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	0.711
p.P179L	SIDM00190	Melanoma	GDSC	PRSELSLIS	DEG_APCC_DBOX_1	0.6471
p.P179L	ACH-002097	Skin Cancer	CCLE	PRSELSLIS	DEG_APCC_DBOX_1	0.6471
p.P179L	CP66-MEL	skin	COSMIC	PRSELSLIS	DEG_APCC_DBOX_1	0.6471
p.S181Y	TCGA-A5-A2K5	UCEC	TCGA	PRSELSLIS	DEG_APCC_DBOX_1	0.6009
p.S181Y	DO41379	UCEC	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	0.6009
p.P179T	TCGA-2G-AAGO	TGCT	TCGA	PRSELSLIS	DEG_APCC_DBOX_1	0.5919
p.R189I	TCGA-EE-A2ME	SKCM	TCGA	PRSELSLIS	DEG_APCC_DBOX_1	0.2778
p.R189I	DO38011	SKCM	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	0.2778
p.R176Q	TCGA-AP-A1DV	UCEC	TCGA	PRSELSLIS	DEG_APCC_DBOX_1	0.25
p.R176Q	DO43186	UCEC	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	0.25
p.R176W	TCGA-D5-6930	COAD	TCGA	PRSELSLIS	DEG_APCC_DBOX_1	0.25
p.R176W	DO10550	COAD	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	0.25
p.R176W	DO228186	LICA	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	0.25
p.R176W	SIDM00983	Bladder Carcinoma	GDSC	PRSELSLIS	DEG_APCC_DBOX_1	0.25
p.R176W	ACH-000896	Bladder Cancer	CCLE	PRSELSLIS	DEG_APCC_DBOX_1	0.25
p.R176W	647-V	urinary_tract	COSMIC	PRSELSLIS	DEG_APCC_DBOX_1	0.25
p.A193P	DO228483	BRCA	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	0.1667
p.A193P	DO229010	COCA	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	0.1667
p.A193P	DO229013	COCA	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	0.1667

Showing 1 to 25 of 35 entries

Show entries

Search:

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
No data available in table

Showing 0 to 0 of 0 entries

Show entries

Search:

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UY14	ADAMTS-like protein 4	DEG_APCC_DBOX_1	179:187	PRSELSLIS	APC,CDC20,FZR1	0.9143	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons