DegronMD

Uniprot ID: Q6UY14

Source protein: ADAMTS-like protein 4

Source gene: ADAMTSL4

Class: DEG_APCC_DBOX_1

Location: 179:187

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9143

ASA_SCORE: 89.0556

COIL: 0.7437

CONS_SCORE: 0.2895

DSS_SCORE: 0.6749

HELIX: 0.2198

FCONS_SCORE: 1.0146

RIG_SCORE: 0.6289

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P179T	TCGA-2G-AAGO	TGCT	TCGA	PRSELSLIS	DEG_APCC_DBOX_1	0.5919
p.S181Y	TCGA-A5-A2K5	UCEC	TCGA	PRSELSLIS	DEG_APCC_DBOX_1	0.6009
p.S181Y	DO41379	UCEC	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	0.6009
p.R176Q	TCGA-AP-A1DV	UCEC	TCGA	PRSELSLIS	DEG_APCC_DBOX_1	0.25
p.R176Q	DO43186	UCEC	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	0.25
p.R170Q	TCGA-BR-A4QL	STAD	TCGA	PRSELSLIS	DEG_APCC_DBOX_1	0.0833
p.R170Q	DO38723	STAD	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	0.0833
p.R172H	TCGA-D5-6534	COAD	TCGA	PRSELSLIS	DEG_APCC_DBOX_1	0.1389
p.R172H	DO10718	COAD	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	0.1389
p.R176W	TCGA-D5-6930	COAD	TCGA	PRSELSLIS	DEG_APCC_DBOX_1	0.25
p.R176W	DO10550	COAD	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	0.25
p.R176W	DO228186	LICA	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	0.25
p.R176W	SIDM00983	Bladder Carcinoma	GDSC	PRSELSLIS	DEG_APCC_DBOX_1	0.25
p.R176W	ACH-000896	Bladder Cancer	CCLE	PRSELSLIS	DEG_APCC_DBOX_1	0.25
p.R176W	647-V	urinary_tract	COSMIC	PRSELSLIS	DEG_APCC_DBOX_1	0.25
p.R189I	TCGA-EE-A2ME	SKCM	TCGA	PRSELSLIS	DEG_APCC_DBOX_1	0.2778
p.R189I	DO38011	SKCM	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	0.2778
p.R180I	TCGA-EO-A22U	UCEC	TCGA	PRSELSLIS	DEG_APCC_DBOX_1	0.8102
p.R180I	DO43755	UCEC	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	0.8102
p.S177T	TCGA-YD-A89C	SKCM	TCGA	PRSELSLIS	DEG_APCC_DBOX_1	0.7222
p.S177T	DO219501	SKCM	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	0.7222
p.A193P	DO228483	BRCA	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	0.1667
p.A193P	DO229010	COCA	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	0.1667
p.A193P	DO229013	COCA	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	0.1667
p.A193P	DO229016	COCA	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	0.1667
p.A193P	DO229480	LAML	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	0.1667
p.A193P	DO225404	LAML	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	0.1667
p.A193P	DO228957	LICA	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	0.1667
p.S177I	DO229028	LICA	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	0.7222
p.R172L	DO229036	LICA	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	0.1389
p.L183M	DO232761	PBCA	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	0.711
p.P179L	SIDM00190	Melanoma	GDSC	PRSELSLIS	DEG_APCC_DBOX_1	0.6471
p.P179L	ACH-002097	Skin Cancer	CCLE	PRSELSLIS	DEG_APCC_DBOX_1	0.6471
p.P179L	CP66-MEL	skin	COSMIC	PRSELSLIS	DEG_APCC_DBOX_1	0.6471
p.R172C	SIDM01772	Mesothelioma	GDSC	PRSELSLIS	DEG_APCC_DBOX_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRSELSLIS

Degron related mutations and impact score

Drug responses associated with ADAMTSL4 mutations

All proteins holding degron of PRSELSLIS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UY14	ADAMTS-like protein 4	DEG_APCC_DBOX_1	179:187	PRSELSLIS	APC,CDC20,FZR1	0.9143	More...