DegronMD - Q6UY14(ADAMTSL4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P179T	TCGA-2G-AAGO	TGCT	TCGA	PRSELSLIS	DEG_APCC_DBOX_1	179:187	Mutation altering degron motif	0.5919
p.P197S	TCGA-73-4668	LUAD	TCGA	PSPTPRAE	DEG_SCF_FBW7_2	195:202	Mutation altering degron motif	0.5641
p.P197S	DO23961	LUAD	ICGC	PSPTPRAE	DEG_SCF_FBW7_2	195:202	Mutation altering degron motif	0.5641
p.F689S	TCGA-85-A50Z	LUSC	TCGA	SRESGE	DEG_Kelch_Keap1_1	693:698	Mutation rewiring degron network	0.2222
p.F689S	DO45462	LUSC	ICGC	SRESGE	DEG_Kelch_Keap1_1	693:698	Mutation rewiring degron network	0.2222
p.E202K	TCGA-A5-A0G2	UCEC	TCGA	PSPTPRAE	DEG_SCF_FBW7_2	195:202	Mutation altering degron motif	0.7022
p.E202K	DO41235	UCEC	ICGC	PSPTPRAE	DEG_SCF_FBW7_2	195:202	Mutation altering degron motif	0.7022
p.S181Y	TCGA-A5-A2K5	UCEC	TCGA	PRSELSLIS	DEG_APCC_DBOX_1	179:187	Mutation altering degron motif	0.6009
p.S181Y	DO41379	UCEC	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	179:187	Mutation altering degron motif	0.6009
p.R686H	TCGA-AP-A059	UCEC	TCGA	SRESGE	DEG_Kelch_Keap1_1	693:698	Mutation rewiring degron network	0.1389
p.R686H	TCGA-AP-A0LM	UCEC	TCGA	SRESGE	DEG_Kelch_Keap1_1	693:698	Mutation rewiring degron network	0.1389
p.R686H	DO227996	COCA	ICGC	SRESGE	DEG_Kelch_Keap1_1	693:698	Mutation rewiring degron network	0.1389
p.R686H	DO43306	UCEC	ICGC	SRESGE	DEG_Kelch_Keap1_1	693:698	Mutation rewiring degron network	0.1389
p.R686H	DO41361	UCEC	ICGC	SRESGE	DEG_Kelch_Keap1_1	693:698	Mutation rewiring degron network	0.1389
p.R647W	TCGA-AP-A0LM	UCEC	TCGA	PRTPLGS	DEG_SCF_FBW7_1	657:663	Mutation rewiring degron network	0.0556
p.R647W	DO43306	UCEC	ICGC	PRTPLGS	DEG_SCF_FBW7_1	657:663	Mutation rewiring degron network	0.0556
p.R176Q	TCGA-AP-A1DV	UCEC	TCGA	PRSELSLIS	DEG_APCC_DBOX_1	179:187	Mutation rewiring degron network	0.25
p.R176Q	DO43186	UCEC	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	179:187	Mutation rewiring degron network	0.25
p.R670Q	TCGA-AX-A1CE	UCEC	TCGA	PRTPLGS	DEG_SCF_FBW7_1	657:663	Mutation rewiring degron network	0.1389
p.R670Q	DO42280	UCEC	ICGC	PRTPLGS	DEG_SCF_FBW7_1	657:663	Mutation rewiring degron network	0.1389
p.R703C	TCGA-AX-A2HD	UCEC	TCGA	SRESGE	DEG_Kelch_Keap1_1	693:698	Mutation rewiring degron network	0.1944
p.R703C	DO42608	UCEC	ICGC	SRESGE	DEG_Kelch_Keap1_1	693:698	Mutation rewiring degron network	0.1944
p.G662R	TCGA-AY-6196	COAD	TCGA	PRTPLGS	DEG_SCF_FBW7_1	657:663	Mutation altering degron motif	0.6457
p.G662R	DO10300	COAD	ICGC	PRTPLGS	DEG_SCF_FBW7_1	657:663	Mutation altering degron motif	0.6457
p.R170Q	TCGA-BR-A4QL	STAD	TCGA	PRSELSLIS	DEG_APCC_DBOX_1	179:187	Mutation rewiring degron network	0.0833
p.R170Q	DO38723	STAD	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	179:187	Mutation rewiring degron network	0.0833
p.R172H	TCGA-D5-6534	COAD	TCGA	PRSELSLIS	DEG_APCC_DBOX_1	179:187	Mutation rewiring degron network	0.1389
p.R172H	DO10718	COAD	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	179:187	Mutation rewiring degron network	0.1389
p.R176W	TCGA-D5-6930	COAD	TCGA	PRSELSLIS	DEG_APCC_DBOX_1	179:187	Mutation rewiring degron network	0.25
p.R176W	DO10550	COAD	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	179:187	Mutation rewiring degron network	0.25
p.R176W	DO228186	LICA	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	179:187	Mutation rewiring degron network	0.25
p.R176W	SIDM00983	Bladder Carcinoma	GDSC	PRSELSLIS	DEG_APCC_DBOX_1	179:187	Mutation rewiring degron network	0.25
p.R176W	ACH-000896	Bladder Cancer	CCLE	PRSELSLIS	DEG_APCC_DBOX_1	179:187	Mutation rewiring degron network	0.25
p.R176W	647-V	urinary tract	COSMIC	PRSELSLIS	DEG_APCC_DBOX_1	179:187	Mutation rewiring degron network	0.25
p.A206T	TCGA-DU-6392	LGG	TCGA	PSPTPRAE	DEG_SCF_FBW7_2	195:202	Mutation rewiring degron network	0.2222
p.A206T	DO22237	LGG	ICGC	PSPTPRAE	DEG_SCF_FBW7_2	195:202	Mutation rewiring degron network	0.2222
p.R189I	TCGA-EE-A2ME	SKCM	TCGA	PRSELSLIS	DEG_APCC_DBOX_1	179:187	Mutation rewiring degron network	0.2778
p.R189I	TCGA-EE-A2ME	SKCM	TCGA	PSPTPRAE	DEG_SCF_FBW7_2	195:202	Mutation rewiring degron network	0.1667
p.R189I	DO38011	SKCM	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	179:187	Mutation rewiring degron network	0.2778
p.R189I	DO38011	SKCM	ICGC	PSPTPRAE	DEG_SCF_FBW7_2	195:202	Mutation rewiring degron network	0.1667
p.R180I	TCGA-EO-A22U	UCEC	TCGA	PRSELSLIS	DEG_APCC_DBOX_1	179:187	Mutation altering degron motif	0.8102
p.R180I	DO43755	UCEC	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	179:187	Mutation altering degron motif	0.8102
p.P197T	TCGA-EO-A3KX	UCEC	TCGA	PSPTPRAE	DEG_SCF_FBW7_2	195:202	Mutation altering degron motif	0.5919
p.P197T	DO219774	UCEC	ICGC	PSPTPRAE	DEG_SCF_FBW7_2	195:202	Mutation altering degron motif	0.5919
p.R703H	TCGA-FI-A2D5	UCEC	TCGA	SRESGE	DEG_Kelch_Keap1_1	693:698	Mutation rewiring degron network	0.1944
p.R703H	DO41331	UCEC	ICGC	SRESGE	DEG_Kelch_Keap1_1	693:698	Mutation rewiring degron network	0.1944
p.E702K	TCGA-FW-A3R5	SKCM	TCGA	SRESGE	DEG_Kelch_Keap1_1	693:698	Mutation rewiring degron network	0.2222
p.E702K	DO37406	SKCM	ICGC	SRESGE	DEG_Kelch_Keap1_1	693:698	Mutation rewiring degron network	0.2222
p.R694S	TCGA-H4-A2HO	BLCA	TCGA	SRESGE	DEG_Kelch_Keap1_1	693:698	Mutation altering degron motif	0.6316
p.R694S	DO494	BLCA	ICGC	SRESGE	DEG_Kelch_Keap1_1	693:698	Mutation altering degron motif	0.6316
p.E695Q	TCGA-IR-A3LK	CESC	TCGA	SRESGE	DEG_Kelch_Keap1_1	693:698	Mutation altering degron motif	0.6744
p.E695Q	DO44299	CESC	ICGC	SRESGE	DEG_Kelch_Keap1_1	693:698	Mutation altering degron motif	0.6744
p.E695Q	DO231997	ORCA	ICGC	SRESGE	DEG_Kelch_Keap1_1	693:698	Mutation altering degron motif	0.6744
p.P654S	TCGA-LN-A49O	ESCA	TCGA	PRTPLGS	DEG_SCF_FBW7_1	657:663	Mutation rewiring degron network	0.25
p.R670P	TCGA-NH-A8F7	COAD	TCGA	PRTPLGS	DEG_SCF_FBW7_1	657:663	Mutation rewiring degron network	0.1389
p.R670P	DO51729	COAD	ICGC	PRTPLGS	DEG_SCF_FBW7_1	657:663	Mutation rewiring degron network	0.1389
p.S177T	TCGA-YD-A89C	SKCM	TCGA	PRSELSLIS	DEG_APCC_DBOX_1	179:187	Mutation blocking phosphorylation signal	0.7222
p.S177T	DO219501	SKCM	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	179:187	Mutation blocking phosphorylation signal	0.7222
p.S696L	DO224996	BRCA	ICGC	SRESGE	DEG_Kelch_Keap1_1	693:698	Mutation altering degron motif	0.8778
p.A193P	DO228483	BRCA	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	179:187	Mutation rewiring degron network	0.1667
p.A193P	DO228483	BRCA	ICGC	PSPTPRAE	DEG_SCF_FBW7_2	195:202	Mutation rewiring degron network	0.2778
p.A193P	DO229010	COCA	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	179:187	Mutation rewiring degron network	0.1667
p.A193P	DO229010	COCA	ICGC	PSPTPRAE	DEG_SCF_FBW7_2	195:202	Mutation rewiring degron network	0.2778
p.A193P	DO229013	COCA	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	179:187	Mutation rewiring degron network	0.1667
p.A193P	DO229013	COCA	ICGC	PSPTPRAE	DEG_SCF_FBW7_2	195:202	Mutation rewiring degron network	0.2778
p.A193P	DO229016	COCA	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	179:187	Mutation rewiring degron network	0.1667
p.A193P	DO229016	COCA	ICGC	PSPTPRAE	DEG_SCF_FBW7_2	195:202	Mutation rewiring degron network	0.2778
p.A193P	DO229480	LAML	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	179:187	Mutation rewiring degron network	0.1667
p.A193P	DO229480	LAML	ICGC	PSPTPRAE	DEG_SCF_FBW7_2	195:202	Mutation rewiring degron network	0.2778
p.A193P	DO225404	LAML	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	179:187	Mutation rewiring degron network	0.1667
p.A193P	DO225404	LAML	ICGC	PSPTPRAE	DEG_SCF_FBW7_2	195:202	Mutation rewiring degron network	0.2778
p.A193P	DO228957	LICA	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	179:187	Mutation rewiring degron network	0.1667
p.A193P	DO228957	LICA	ICGC	PSPTPRAE	DEG_SCF_FBW7_2	195:202	Mutation rewiring degron network	0.2778
p.A653T	DO222806	COCA	ICGC	PRTPLGS	DEG_SCF_FBW7_1	657:663	Mutation rewiring degron network	0.2222
p.A706S	DO228978	LICA	ICGC	SRESGE	DEG_Kelch_Keap1_1	693:698	Mutation rewiring degron network	0.1111
p.G697V	DO228971	LICA	ICGC	SRESGE	DEG_Kelch_Keap1_1	693:698	Mutation altering degron motif	0.7532
p.S177I	DO229028	LICA	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	179:187	Mutation blocking phosphorylation signal	0.7222
p.A665S	DO229025	LICA	ICGC	PRTPLGS	DEG_SCF_FBW7_1	657:663	Mutation rewiring degron network	0.2778
p.R172L	DO229036	LICA	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	179:187	Mutation rewiring degron network	0.1389
p.L183M	DO232761	PBCA	ICGC	PRSELSLIS	DEG_APCC_DBOX_1	179:187	Mutation altering degron motif	0.711
p.E695V	DO47753	STAD	ICGC	SRESGE	DEG_Kelch_Keap1_1	693:698	Mutation altering degron motif	0.7693
p.R667H	SIDM02038	Colorectal Carcinoma	GDSC	PRTPLGS	DEG_SCF_FBW7_1	657:663	Mutation rewiring degron network	0.2222
p.P195L	SIDM01090	Colorectal Carcinoma	GDSC	PSPTPRAE	DEG_SCF_FBW7_2	195:202	Mutation altering degron motif	0.6471
p.P195L	SIDM01112	Osteosarcoma	GDSC	PSPTPRAE	DEG_SCF_FBW7_2	195:202	Mutation altering degron motif	0.6471
p.A659T	SIDM00096	T-Cell Non-Hodgkin's Lymphoma	GDSC	PRTPLGS	DEG_SCF_FBW7_1	657:663	Mutation altering degron motif	0.7139
p.A659T	SR	haematopoietic and lymphoid tissue	COSMIC	PRTPLGS	DEG_SCF_FBW7_1	657:663	Mutation altering degron motif	0.7139
p.P179L	SIDM00190	Melanoma	GDSC	PRSELSLIS	DEG_APCC_DBOX_1	179:187	Mutation altering degron motif	0.6471
p.P179L	ACH-002097	Skin Cancer	CCLE	PRSELSLIS	DEG_APCC_DBOX_1	179:187	Mutation altering degron motif	0.6471
p.P179L	CP66-MEL	skin	COSMIC	PRSELSLIS	DEG_APCC_DBOX_1	179:187	Mutation altering degron motif	0.6471
p.G208S	SIDM00068	Colorectal Carcinoma	GDSC	PSPTPRAE	DEG_SCF_FBW7_2	195:202	Mutation rewiring degron network	0.1667
p.G208S	SIDM01173	Rhabdomyosarcoma	GDSC	PSPTPRAE	DEG_SCF_FBW7_2	195:202	Mutation rewiring degron network	0.1667
p.Q211K	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PSPTPRAE	DEG_SCF_FBW7_2	195:202	Mutation rewiring degron network	0.0833
p.Q211K	ACH-001127	Leukemia	CCLE	PSPTPRAE	DEG_SCF_FBW7_2	195:202	Mutation rewiring degron network	0.0833
p.Q211K	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PSPTPRAE	DEG_SCF_FBW7_2	195:202	Mutation rewiring degron network	0.0833
p.C703Y	SIDM01228	Melanoma	GDSC	SRESGE	DEG_Kelch_Keap1_1	693:698	Mutation rewiring degron network	0.1944
p.C703Y	CHL-1	skin	COSMIC	SRESGE	DEG_Kelch_Keap1_1	693:698	Mutation rewiring degron network	0.1944
p.R172C	SIDM01772	Mesothelioma	GDSC	PRSELSLIS	DEG_APCC_DBOX_1	179:187	Mutation rewiring degron network	0.1389
p.R667C	SIDM01588	Endometrial Carcinoma	GDSC	PRTPLGS	DEG_SCF_FBW7_1	657:663	Mutation rewiring degron network	0.2222
p.P649S	ACH-000999	Colon/Colorectal Cancer	CCLE	PRTPLGS	DEG_SCF_FBW7_1	657:663	Mutation rewiring degron network	0.1111
p.P649H	ACH-001033	Unknown	CCLE	PRTPLGS	DEG_SCF_FBW7_1	657:663	Mutation rewiring degron network	0.1111
p.A707V	LIM1215	large intestine	COSMIC	SRESGE	DEG_Kelch_Keap1_1	693:698	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ADAMTSL4

UniProt ID: Q6UY14

Entrez ID: 54507

Protein name: ADAMTS-like protein 4 (ADAMTSL-4) (Thrombospondin repeat-containing protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ADAMTSL4 in