DegronMD

Uniprot ID: Q6UY14

Source protein: ADAMTS-like protein 4

Source gene: ADAMTSL4

Class: DEG_SCF_FBW7_1

Location: 657:663

E3 ligase: FBXW7

DEGRON score: 0.9169

ASA_SCORE: 82.6714

COIL: 0.9149

CONS_SCORE: 0.4295

DSS_SCORE: 0.5401

HELIX: 0.0337

FCONS_SCORE: 0.9819

RIG_SCORE: 0.6267

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R647W	TCGA-AP-A0LM	UCEC	TCGA	PRTPLGS	DEG_SCF_FBW7_1	0.0556
p.R647W	DO43306	UCEC	ICGC	PRTPLGS	DEG_SCF_FBW7_1	0.0556
p.R670Q	TCGA-AX-A1CE	UCEC	TCGA	PRTPLGS	DEG_SCF_FBW7_1	0.1389
p.R670Q	DO42280	UCEC	ICGC	PRTPLGS	DEG_SCF_FBW7_1	0.1389
p.G662R	TCGA-AY-6196	COAD	TCGA	PRTPLGS	DEG_SCF_FBW7_1	0.6457
p.G662R	DO10300	COAD	ICGC	PRTPLGS	DEG_SCF_FBW7_1	0.6457
p.P654S	TCGA-LN-A49O	ESCA	TCGA	PRTPLGS	DEG_SCF_FBW7_1	0.25
p.R670P	TCGA-NH-A8F7	COAD	TCGA	PRTPLGS	DEG_SCF_FBW7_1	0.1389
p.R670P	DO51729	COAD	ICGC	PRTPLGS	DEG_SCF_FBW7_1	0.1389
p.A653T	DO222806	COCA	ICGC	PRTPLGS	DEG_SCF_FBW7_1	0.2222
p.A665S	DO229025	LICA	ICGC	PRTPLGS	DEG_SCF_FBW7_1	0.2778
p.R667H	SIDM02038	Colorectal Carcinoma	GDSC	PRTPLGS	DEG_SCF_FBW7_1	0.2222
p.A659T	SIDM00096	T-Cell Non-Hodgkin's Lymphoma	GDSC	PRTPLGS	DEG_SCF_FBW7_1	0.7139
p.A659T	SR	haematopoietic_and_lymphoid_tissue	COSMIC	PRTPLGS	DEG_SCF_FBW7_1	0.7139
p.R667C	SIDM01588	Endometrial Carcinoma	GDSC	PRTPLGS	DEG_SCF_FBW7_1	0.2222
p.P649S	ACH-000999	Colon/Colorectal Cancer	CCLE	PRTPLGS	DEG_SCF_FBW7_1	0.1111
p.P649H	ACH-001033	Unknown	CCLE	PRTPLGS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UY14	ADAMTS-like protein 4	DEG_SCF_FBW7_1	657:663	PRTPLGS	FBXW7	0.9169	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons