DegronMD

Uniprot ID: Q6UY14

Source protein: ADAMTS-like protein 4

Source gene: ADAMTSL4

Class: DEG_Kelch_Keap1_1

Location: 693:698

E3 ligase: KEAP1

DEGRON score: 0.7937

ASA_SCORE: 86.6667

COIL: 0.7948

CONS_SCORE: 0.4544

DSS_SCORE: 0.2112

HELIX: 0.008

FCONS_SCORE: 0.8687

RIG_SCORE: 0.7396

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S696L	DO224996	BRCA	ICGC	SRESGE	DEG_Kelch_Keap1_1	0.8778
p.E695V	DO47753	STAD	ICGC	SRESGE	DEG_Kelch_Keap1_1	0.7693
p.G697V	DO228971	LICA	ICGC	SRESGE	DEG_Kelch_Keap1_1	0.7532
p.E695Q	TCGA-IR-A3LK	CESC	TCGA	SRESGE	DEG_Kelch_Keap1_1	0.6744
p.E695Q	DO44299	CESC	ICGC	SRESGE	DEG_Kelch_Keap1_1	0.6744
p.E695Q	DO231997	ORCA	ICGC	SRESGE	DEG_Kelch_Keap1_1	0.6744
p.R694S	TCGA-H4-A2HO	BLCA	TCGA	SRESGE	DEG_Kelch_Keap1_1	0.6316
p.R694S	DO494	BLCA	ICGC	SRESGE	DEG_Kelch_Keap1_1	0.6316
p.F689S	TCGA-85-A50Z	LUSC	TCGA	SRESGE	DEG_Kelch_Keap1_1	0.2222
p.F689S	DO45462	LUSC	ICGC	SRESGE	DEG_Kelch_Keap1_1	0.2222
p.E702K	TCGA-FW-A3R5	SKCM	TCGA	SRESGE	DEG_Kelch_Keap1_1	0.2222
p.E702K	DO37406	SKCM	ICGC	SRESGE	DEG_Kelch_Keap1_1	0.2222
p.R703C	TCGA-AX-A2HD	UCEC	TCGA	SRESGE	DEG_Kelch_Keap1_1	0.1944
p.R703C	DO42608	UCEC	ICGC	SRESGE	DEG_Kelch_Keap1_1	0.1944
p.R703H	TCGA-FI-A2D5	UCEC	TCGA	SRESGE	DEG_Kelch_Keap1_1	0.1944
p.R703H	DO41331	UCEC	ICGC	SRESGE	DEG_Kelch_Keap1_1	0.1944
p.C703Y	SIDM01228	Melanoma	GDSC	SRESGE	DEG_Kelch_Keap1_1	0.1944
p.C703Y	CHL-1	skin	COSMIC	SRESGE	DEG_Kelch_Keap1_1	0.1944
p.R686H	TCGA-AP-A059	UCEC	TCGA	SRESGE	DEG_Kelch_Keap1_1	0.1389
p.R686H	TCGA-AP-A0LM	UCEC	TCGA	SRESGE	DEG_Kelch_Keap1_1	0.1389
p.R686H	DO227996	COCA	ICGC	SRESGE	DEG_Kelch_Keap1_1	0.1389
p.R686H	DO43306	UCEC	ICGC	SRESGE	DEG_Kelch_Keap1_1	0.1389
p.R686H	DO41361	UCEC	ICGC	SRESGE	DEG_Kelch_Keap1_1	0.1389
p.A706S	DO228978	LICA	ICGC	SRESGE	DEG_Kelch_Keap1_1	0.1111
p.A707V	LIM1215	large_intestine	COSMIC	SRESGE	DEG_Kelch_Keap1_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UY14	ADAMTS-like protein 4	DEG_Kelch_Keap1_1	693:698	SRESGE	KEAP1	0.7937	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons