DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PSPTPRAE
Uniprot ID:
Q6UY14
Source protein:
ADAMTS-like protein 4
Source gene:
ADAMTSL4
Class:
DEG_SCF_FBW7_2
Location:
195:202
E3 ligase:
FBXW7
DEGRON score:
0.9934
ASA_SCORE:
98.2
COIL:
0.9495
CONS_SCORE:
0.2751
DSS_SCORE:
0.7436
HELIX:
0.0274
FCONS_SCORE:
1.152
RIG_SCORE:
0.5731
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P197S
TCGA-73-4668
LUAD
TCGA
PSPTPRAE
DEG_SCF_FBW7_2
0.5641
p.P197S
DO23961
LUAD
ICGC
PSPTPRAE
DEG_SCF_FBW7_2
0.5641
p.E202K
TCGA-A5-A0G2
UCEC
TCGA
PSPTPRAE
DEG_SCF_FBW7_2
0.7022
p.E202K
DO41235
UCEC
ICGC
PSPTPRAE
DEG_SCF_FBW7_2
0.7022
p.A206T
TCGA-DU-6392
LGG
TCGA
PSPTPRAE
DEG_SCF_FBW7_2
0.2222
p.A206T
DO22237
LGG
ICGC
PSPTPRAE
DEG_SCF_FBW7_2
0.2222
p.R189I
TCGA-EE-A2ME
SKCM
TCGA
PSPTPRAE
DEG_SCF_FBW7_2
0.1667
p.R189I
DO38011
SKCM
ICGC
PSPTPRAE
DEG_SCF_FBW7_2
0.1667
p.P197T
TCGA-EO-A3KX
UCEC
TCGA
PSPTPRAE
DEG_SCF_FBW7_2
0.5919
p.P197T
DO219774
UCEC
ICGC
PSPTPRAE
DEG_SCF_FBW7_2
0.5919
p.A193P
DO228483
BRCA
ICGC
PSPTPRAE
DEG_SCF_FBW7_2
0.2778
p.A193P
DO229010
COCA
ICGC
PSPTPRAE
DEG_SCF_FBW7_2
0.2778
p.A193P
DO229013
COCA
ICGC
PSPTPRAE
DEG_SCF_FBW7_2
0.2778
p.A193P
DO229016
COCA
ICGC
PSPTPRAE
DEG_SCF_FBW7_2
0.2778
p.A193P
DO229480
LAML
ICGC
PSPTPRAE
DEG_SCF_FBW7_2
0.2778
p.A193P
DO225404
LAML
ICGC
PSPTPRAE
DEG_SCF_FBW7_2
0.2778
p.A193P
DO228957
LICA
ICGC
PSPTPRAE
DEG_SCF_FBW7_2
0.2778
p.P195L
SIDM01090
Colorectal Carcinoma
GDSC
PSPTPRAE
DEG_SCF_FBW7_2
0.6471
p.P195L
SIDM01112
Osteosarcoma
GDSC
PSPTPRAE
DEG_SCF_FBW7_2
0.6471
p.G208S
SIDM00068
Colorectal Carcinoma
GDSC
PSPTPRAE
DEG_SCF_FBW7_2
0.1667
p.G208S
SIDM01173
Rhabdomyosarcoma
GDSC
PSPTPRAE
DEG_SCF_FBW7_2
0.1667
p.Q211K
SIDM00145
T-Lymphoblastic Leukemia
GDSC
PSPTPRAE
DEG_SCF_FBW7_2
0.0833
p.Q211K
ACH-001127
Leukemia
CCLE
PSPTPRAE
DEG_SCF_FBW7_2
0.0833
p.Q211K
MOLT-4
haematopoietic_and_lymphoid_tissue
COSMIC
PSPTPRAE
DEG_SCF_FBW7_2
0.0833
Drug responses associated with ADAMTSL4 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PSPTPRAE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6UY14
ADAMTS-like protein 4
DEG_SCF_FBW7_2
195:202
PSPTPRAE
FBXW7
0.9934
More...