DegronMD

Uniprot ID: Q6UY14

Source protein: ADAMTS-like protein 4

Source gene: ADAMTSL4

Class: DEG_SCF_FBW7_2

Location: 195:202

E3 ligase: FBXW7

DEGRON score: 0.9934

ASA_SCORE: 98.2

COIL: 0.9495

CONS_SCORE: 0.2751

DSS_SCORE: 0.7436

HELIX: 0.0274

FCONS_SCORE: 1.152

RIG_SCORE: 0.5731

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E202K	TCGA-A5-A0G2	UCEC	TCGA	PSPTPRAE	DEG_SCF_FBW7_2	0.7022
p.E202K	DO41235	UCEC	ICGC	PSPTPRAE	DEG_SCF_FBW7_2	0.7022
p.P195L	SIDM01090	Colorectal Carcinoma	GDSC	PSPTPRAE	DEG_SCF_FBW7_2	0.6471
p.P195L	SIDM01112	Osteosarcoma	GDSC	PSPTPRAE	DEG_SCF_FBW7_2	0.6471
p.P197T	TCGA-EO-A3KX	UCEC	TCGA	PSPTPRAE	DEG_SCF_FBW7_2	0.5919
p.P197T	DO219774	UCEC	ICGC	PSPTPRAE	DEG_SCF_FBW7_2	0.5919
p.P197S	TCGA-73-4668	LUAD	TCGA	PSPTPRAE	DEG_SCF_FBW7_2	0.5641
p.P197S	DO23961	LUAD	ICGC	PSPTPRAE	DEG_SCF_FBW7_2	0.5641
p.A193P	DO228483	BRCA	ICGC	PSPTPRAE	DEG_SCF_FBW7_2	0.2778
p.A193P	DO229010	COCA	ICGC	PSPTPRAE	DEG_SCF_FBW7_2	0.2778
p.A193P	DO229013	COCA	ICGC	PSPTPRAE	DEG_SCF_FBW7_2	0.2778
p.A193P	DO229016	COCA	ICGC	PSPTPRAE	DEG_SCF_FBW7_2	0.2778
p.A193P	DO229480	LAML	ICGC	PSPTPRAE	DEG_SCF_FBW7_2	0.2778
p.A193P	DO225404	LAML	ICGC	PSPTPRAE	DEG_SCF_FBW7_2	0.2778
p.A193P	DO228957	LICA	ICGC	PSPTPRAE	DEG_SCF_FBW7_2	0.2778
p.A206T	TCGA-DU-6392	LGG	TCGA	PSPTPRAE	DEG_SCF_FBW7_2	0.2222
p.A206T	DO22237	LGG	ICGC	PSPTPRAE	DEG_SCF_FBW7_2	0.2222
p.R189I	TCGA-EE-A2ME	SKCM	TCGA	PSPTPRAE	DEG_SCF_FBW7_2	0.1667
p.R189I	DO38011	SKCM	ICGC	PSPTPRAE	DEG_SCF_FBW7_2	0.1667
p.G208S	SIDM00068	Colorectal Carcinoma	GDSC	PSPTPRAE	DEG_SCF_FBW7_2	0.1667
p.G208S	SIDM01173	Rhabdomyosarcoma	GDSC	PSPTPRAE	DEG_SCF_FBW7_2	0.1667
p.Q211K	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PSPTPRAE	DEG_SCF_FBW7_2	0.0833
p.Q211K	ACH-001127	Leukemia	CCLE	PSPTPRAE	DEG_SCF_FBW7_2	0.0833
p.Q211K	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PSPTPRAE	DEG_SCF_FBW7_2	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UY14	ADAMTS-like protein 4	DEG_SCF_FBW7_2	195:202	PSPTPRAE	FBXW7	0.9934	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons