DegronMD

Uniprot ID: Q86TI0

Source protein: TBC1 domain family member 1

Source gene: TBC1D1

Class: DEG_APCC_DBOX_1

Location: 693:701

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9964

ASA_SCORE: 82.0444

COIL: 0.8909

CONS_SCORE: 0.3961

DSS_SCORE: 0.649

HELIX: 0.0449

FCONS_SCORE: 1.2628

RIG_SCORE: 0.6165

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R694Q	TCGA-A5-A0G2	UCEC	TCGA	PRSPLEPVC	DEG_APCC_DBOX_1	0.7329
p.R694Q	TCGA-AP-A0LM	UCEC	TCGA	PRSPLEPVC	DEG_APCC_DBOX_1	0.7329
p.R694Q	DO43306	UCEC	ICGC	PRSPLEPVC	DEG_APCC_DBOX_1	0.7329
p.R694Q	DO41235	UCEC	ICGC	PRSPLEPVC	DEG_APCC_DBOX_1	0.7329
p.P699L	TCGA-49-AAR9	LUAD	TCGA	PRSPLEPVC	DEG_APCC_DBOX_1	0.6471
p.P699L	TCGA-A5-A0G1	UCEC	TCGA	PRSPLEPVC	DEG_APCC_DBOX_1	0.6471
p.P699L	DO218921	LUAD	ICGC	PRSPLEPVC	DEG_APCC_DBOX_1	0.6471
p.P699L	DO42472	UCEC	ICGC	PRSPLEPVC	DEG_APCC_DBOX_1	0.6471
p.E702K	DO46546	OV	ICGC	PRSPLEPVC	DEG_APCC_DBOX_1	0.3056
p.L691H	TCGA-D9-A148	SKCM	TCGA	PRSPLEPVC	DEG_APCC_DBOX_1	0.2778
p.L691H	DO37971	SKCM	ICGC	PRSPLEPVC	DEG_APCC_DBOX_1	0.2778
p.D703Y	DO229036	LICA	ICGC	PRSPLEPVC	DEG_APCC_DBOX_1	0.2778
p.K690N	DO220007	SARC	ICGC	PRSPLEPVC	DEG_APCC_DBOX_1	0.25
p.A687V	DO223282	UCEC	ICGC	PRSPLEPVC	DEG_APCC_DBOX_1	0.1667
p.V708L	DO229045	LICA	ICGC	PRSPLEPVC	DEG_APCC_DBOX_1	0.1389
p.P709S	TCGA-21-1079	LUSC	TCGA	PRSPLEPVC	DEG_APCC_DBOX_1	0.1111
p.P709S	DO26846	LUSC	ICGC	PRSPLEPVC	DEG_APCC_DBOX_1	0.1111
p.S684R	A498	kidney	COSMIC	PRSPLEPVC	DEG_APCC_DBOX_1	0.0833

Showing 1 to 18 of 18 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86TI0	TBC1 domain family member 1	DEG_APCC_DBOX_1	693:701	PRSPLEPVC	APC,CDC20,FZR1	0.9964	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons