DegronMD - Q86TI0(TBC1D1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P709S	TCGA-21-1079	LUSC	TCGA	PRSPLEPVC	DEG_APCC_DBOX_1	693:701	Mutation rewiring degron network	0.1111
p.P709S	DO26846	LUSC	ICGC	PRSPLEPVC	DEG_APCC_DBOX_1	693:701	Mutation rewiring degron network	0.1111
p.P699L	TCGA-49-AAR9	LUAD	TCGA	PRSPLEPVC	DEG_APCC_DBOX_1	693:701	Mutation altering degron motif	0.6471
p.P699L	TCGA-A5-A0G1	UCEC	TCGA	PRSPLEPVC	DEG_APCC_DBOX_1	693:701	Mutation altering degron motif	0.6471
p.P699L	DO218921	LUAD	ICGC	PRSPLEPVC	DEG_APCC_DBOX_1	693:701	Mutation altering degron motif	0.6471
p.P699L	DO42472	UCEC	ICGC	PRSPLEPVC	DEG_APCC_DBOX_1	693:701	Mutation altering degron motif	0.6471
p.R694Q	TCGA-A5-A0G2	UCEC	TCGA	PRSPLEPVC	DEG_APCC_DBOX_1	693:701	Mutation altering degron motif	0.7329
p.R694Q	TCGA-AP-A0LM	UCEC	TCGA	PRSPLEPVC	DEG_APCC_DBOX_1	693:701	Mutation altering degron motif	0.7329
p.R694Q	DO43306	UCEC	ICGC	PRSPLEPVC	DEG_APCC_DBOX_1	693:701	Mutation altering degron motif	0.7329
p.R694Q	DO41235	UCEC	ICGC	PRSPLEPVC	DEG_APCC_DBOX_1	693:701	Mutation altering degron motif	0.7329
p.K501E	TCGA-AX-A06F	UCEC	TCGA	TRFRLDMLK	DEG_APCC_DBOX_1	489:497	Mutation substituting flanking lysine	0.3333
p.K501E	DO41752	UCEC	ICGC	TRFRLDMLK	DEG_APCC_DBOX_1	489:497	Mutation substituting flanking lysine	0.3333
p.N479H	TCGA-AX-A0J0	UCEC	TCGA	TRFRLDMLK	DEG_APCC_DBOX_1	489:497	Mutation rewiring degron network	0.0556
p.N479H	DO41133	UCEC	ICGC	TRFRLDMLK	DEG_APCC_DBOX_1	489:497	Mutation rewiring degron network	0.0556
p.F491V	TCGA-BR-8687	STAD	TCGA	TRFRLDMLK	DEG_APCC_DBOX_1	489:497	Mutation altering degron motif	0.5957
p.F491V	DO47801	STAD	ICGC	TRFRLDMLK	DEG_APCC_DBOX_1	489:497	Mutation altering degron motif	0.5957
p.L691H	TCGA-D9-A148	SKCM	TCGA	PRSPLEPVC	DEG_APCC_DBOX_1	693:701	Mutation rewiring degron network	0.2778
p.L691H	DO37971	SKCM	ICGC	PRSPLEPVC	DEG_APCC_DBOX_1	693:701	Mutation rewiring degron network	0.2778
p.S503Y	TCGA-ND-A4WC	UCS	TCGA	TRFRLDMLK	DEG_APCC_DBOX_1	489:497	Mutation blocking phosphorylation signal	0.6111
p.D703Y	DO229036	LICA	ICGC	PRSPLEPVC	DEG_APCC_DBOX_1	693:701	Mutation rewiring degron network	0.2778
p.V708L	DO229045	LICA	ICGC	PRSPLEPVC	DEG_APCC_DBOX_1	693:701	Mutation rewiring degron network	0.1389
p.E702K	DO46546	OV	ICGC	PRSPLEPVC	DEG_APCC_DBOX_1	693:701	Mutation rewiring degron network	0.3056
p.K690N	DO220007	SARC	ICGC	PRSPLEPVC	DEG_APCC_DBOX_1	693:701	Mutation rewiring degron network	0.25
p.A687V	DO223282	UCEC	ICGC	PRSPLEPVC	DEG_APCC_DBOX_1	693:701	Mutation rewiring degron network	0.1667
p.K499E	SIDM01199	Hepatocellular Carcinoma	GDSC	TRFRLDMLK	DEG_APCC_DBOX_1	489:497	Mutation rewiring degron network	0.2778
p.K499E	SNU-423	liver	COSMIC	TRFRLDMLK	DEG_APCC_DBOX_1	489:497	Mutation rewiring degron network	0.2778
p.R502T	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	TRFRLDMLK	DEG_APCC_DBOX_1	489:497	Mutation rewiring degron network	0.1944
p.R502T	H513	pleura	COSMIC	TRFRLDMLK	DEG_APCC_DBOX_1	489:497	Mutation rewiring degron network	0.1944
p.R492S	SIDM00420	Bladder Carcinoma	GDSC	TRFRLDMLK	DEG_APCC_DBOX_1	489:497	Mutation altering degron motif	0.6316
p.R492S	ACH-000566	Bladder Cancer	CCLE	TRFRLDMLK	DEG_APCC_DBOX_1	489:497	Mutation altering degron motif	0.6316
p.R492S	SW1710	urinary tract	COSMIC	TRFRLDMLK	DEG_APCC_DBOX_1	489:497	Mutation altering degron motif	0.6316
p.L504V	SIDM00145	T-Lymphoblastic Leukemia	GDSC	TRFRLDMLK	DEG_APCC_DBOX_1	489:497	Mutation rewiring degron network	0.1389
p.L504V	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	TRFRLDMLK	DEG_APCC_DBOX_1	489:497	Mutation rewiring degron network	0.1389
p.N479Y	SIDM01582	Gastric Carcinoma	GDSC	TRFRLDMLK	DEG_APCC_DBOX_1	489:497	Mutation rewiring degron network	0.0556
p.N479Y	ACH-000507	Gastric Cancer	CCLE	TRFRLDMLK	DEG_APCC_DBOX_1	489:497	Mutation rewiring degron network	0.0556
p.S684R	A498	kidney	COSMIC	PRSPLEPVC	DEG_APCC_DBOX_1	693:701	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TBC1D1

UniProt ID: Q86TI0

Entrez ID: 23216

Protein name: TBC1 domain family member 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TBC1D1 in