DegronMD

Uniprot ID: Q86TI0

Source protein: TBC1 domain family member 1

Source gene: TBC1D1

Class: DEG_APCC_DBOX_1

Location: 489:497

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.774

ASA_SCORE: 97.1889

COIL: 0.3298

CONS_SCORE: 0.3201

DSS_SCORE: 0.4924

HELIX: 0.6574

FCONS_SCORE: 0.7893

RIG_SCORE: 0.8028

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K501E	TCGA-AX-A06F	UCEC	TCGA	TRFRLDMLK	DEG_APCC_DBOX_1	0.3333
p.K501E	DO41752	UCEC	ICGC	TRFRLDMLK	DEG_APCC_DBOX_1	0.3333
p.N479H	TCGA-AX-A0J0	UCEC	TCGA	TRFRLDMLK	DEG_APCC_DBOX_1	0.0556
p.N479H	DO41133	UCEC	ICGC	TRFRLDMLK	DEG_APCC_DBOX_1	0.0556
p.F491V	TCGA-BR-8687	STAD	TCGA	TRFRLDMLK	DEG_APCC_DBOX_1	0.5957
p.F491V	DO47801	STAD	ICGC	TRFRLDMLK	DEG_APCC_DBOX_1	0.5957
p.S503Y	TCGA-ND-A4WC	UCS	TCGA	TRFRLDMLK	DEG_APCC_DBOX_1	0.6111
p.K499E	SIDM01199	Hepatocellular Carcinoma	GDSC	TRFRLDMLK	DEG_APCC_DBOX_1	0.2778
p.K499E	SNU-423	liver	COSMIC	TRFRLDMLK	DEG_APCC_DBOX_1	0.2778
p.R502T	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	TRFRLDMLK	DEG_APCC_DBOX_1	0.1944
p.R502T	H513	pleura	COSMIC	TRFRLDMLK	DEG_APCC_DBOX_1	0.1944
p.R492S	SIDM00420	Bladder Carcinoma	GDSC	TRFRLDMLK	DEG_APCC_DBOX_1	0.6316
p.R492S	ACH-000566	Bladder Cancer	CCLE	TRFRLDMLK	DEG_APCC_DBOX_1	0.6316
p.R492S	SW1710	urinary_tract	COSMIC	TRFRLDMLK	DEG_APCC_DBOX_1	0.6316
p.L504V	SIDM00145	T-Lymphoblastic Leukemia	GDSC	TRFRLDMLK	DEG_APCC_DBOX_1	0.1389
p.L504V	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	TRFRLDMLK	DEG_APCC_DBOX_1	0.1389
p.N479Y	SIDM01582	Gastric Carcinoma	GDSC	TRFRLDMLK	DEG_APCC_DBOX_1	0.0556
p.N479Y	ACH-000507	Gastric Cancer	CCLE	TRFRLDMLK	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86TI0	TBC1 domain family member 1	DEG_APCC_DBOX_1	489:497	TRFRLDMLK	APC,CDC20,FZR1	0.774	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons