DegronMD

Uniprot ID: Q9UH99

Source protein: SUN domain-containing protein 2

Source gene: SUN2

Class: DEG_APCC_DBOX_1

Location: 82:90

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9205

ASA_SCORE: 84.7

COIL: 0.6583

CONS_SCORE: 0.2993

DSS_SCORE: 0.3935

HELIX: 0.2061

FCONS_SCORE: 1.0352

RIG_SCORE: 0.6942

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A93T	TCGA-AX-A1CE	UCEC	TCGA	PRSSLEELH	DEG_APCC_DBOX_1	0.25
p.A93T	DO42280	UCEC	ICGC	PRSSLEELH	DEG_APCC_DBOX_1	0.25
p.M85L	DO49343	ALL	ICGC	PRSSLEELH	DEG_APCC_DBOX_1	0.711
p.L89R	DO228941	LICA	ICGC	PRSSLEELH	DEG_APCC_DBOX_1	0.8428

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UH99	SUN domain-containing protein 2	DEG_APCC_DBOX_1	82:90	PRSSLEELH	APC,CDC20,FZR1	0.9205	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons