DegronMD - Q9UH99(SUN2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q701E	TCGA-57-1992	OV	TCGA	RFRVHGE	LIG_APCC_ABBAyCdc20_2	708:714	Mutation rewiring degron network	0.1389
p.E723K	TCGA-AA-3855	COAD	TCGA	RFRVHGE	LIG_APCC_ABBAyCdc20_2	708:714	Mutation rewiring degron network	0.0833
p.E723K	SIDM01667	B-Cell Non-Hodgkin's Lymphoma	GDSC	RFRVHGE	LIG_APCC_ABBAyCdc20_2	708:714	Mutation rewiring degron network	0.0833
p.A93T	TCGA-AX-A1CE	UCEC	TCGA	PRSSLEELH	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.25
p.A93T	DO42280	UCEC	ICGC	PRSSLEELH	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.25
p.T704M	TCGA-D1-A103	UCEC	TCGA	RFRVHGE	LIG_APCC_ABBAyCdc20_2	708:714	Mutation rewiring degron network	0.2222
p.R714L	TCGA-EE-A17Z	SKCM	TCGA	RFRVHGE	LIG_APCC_ABBAyCdc20_2	708:714	Mutation altering degron motif	0.8428
p.M85L	DO49343	ALL	ICGC	PRSSLEELH	DEG_APCC_DBOX_1	82:90	Mutation altering degron motif	0.711
p.E702K	DO10742	COAD	ICGC	RFRVHGE	LIG_APCC_ABBAyCdc20_2	708:714	Mutation rewiring degron network	0.1667
p.E702K	ACH-000220	Lymphoma	CCLE	RFRVHGE	LIG_APCC_ABBAyCdc20_2	708:714	Mutation rewiring degron network	0.1667
p.L89R	DO228941	LICA	ICGC	PRSSLEELH	DEG_APCC_DBOX_1	82:90	Mutation altering degron motif	0.8428
p.H712N	DO229046	LICA	ICGC	RFRVHGE	LIG_APCC_ABBAyCdc20_2	708:714	Mutation altering degron motif	0.7423
p.R708C	DO50118	STAD	ICGC	RFRVHGE	LIG_APCC_ABBAyCdc20_2	708:714	Mutation altering degron motif	0.8301
p.R708C	DO41644	UCEC	ICGC	RFRVHGE	LIG_APCC_ABBAyCdc20_2	708:714	Mutation altering degron motif	0.8301
p.A716T	DO38404	STAD	ICGC	RFRVHGE	LIG_APCC_ABBAyCdc20_2	708:714	Mutation rewiring degron network	0.2778
p.R714Q	SIDM02059	Colorectal Carcinoma	GDSC	RFRVHGE	LIG_APCC_ABBAyCdc20_2	708:714	Mutation altering degron motif	0.7329
p.W719C	SIDM00057	Neuroblastoma	GDSC	RFRVHGE	LIG_APCC_ABBAyCdc20_2	708:714	Mutation rewiring degron network	0.1944
p.W719C	ACN	autonomic ganglia	COSMIC	RFRVHGE	LIG_APCC_ABBAyCdc20_2	708:714	Mutation rewiring degron network	0.1944
p.T707M	SIDM00474	Ovarian Carcinoma	GDSC	RFRVHGE	LIG_APCC_ABBAyCdc20_2	708:714	Mutation rewiring degron network	0.3056
p.T707M	SIDM00126	Melanoma	GDSC	RFRVHGE	LIG_APCC_ABBAyCdc20_2	708:714	Mutation rewiring degron network	0.3056
p.W698C	ACH-000676	Brain Cancer	CCLE	RFRVHGE	LIG_APCC_ABBAyCdc20_2	708:714	Mutation rewiring degron network	0.0556
p.W698C	ACH-002389	Neuroblastoma	CCLE	RFRVHGE	LIG_APCC_ABBAyCdc20_2	708:714	Mutation rewiring degron network	0.0556
p.W698C	ACN	autonomic ganglia	COSMIC	RFRVHGE	LIG_APCC_ABBAyCdc20_2	708:714	Mutation rewiring degron network	0.0556
p.P715S	ACH-002351	Non-Cancerous	CCLE	RFRVHGE	LIG_APCC_ABBAyCdc20_2	708:714	Mutation rewiring degron network	0.3056

Kaplan plot for SUN2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SUN2

UniProt ID: Q9UH99

Entrez ID: 25777

Protein name: SUN domain-containing protein 2 (Protein unc-84 homolog B) (Rab5-interacting protein) (Rab5IP) (Sad1/unc-84 protein-like 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SUN2 in