DegronMD

Uniprot ID: Q9UH99

Source protein: SUN domain-containing protein 2

Source gene: SUN2

Class: LIG_APCC_ABBAyCdc20_2

Location: 708:714

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8446

ASA_SCORE: 54.3857

COIL: 0.3254

CONS_SCORE: 0.7737

DSS_SCORE: 0.3227

HELIX: 0.0037

FCONS_SCORE: 1.246

RIG_SCORE: 0.8015

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q701E	TCGA-57-1992	OV	TCGA	RFRVHGE	LIG_APCC_ABBAyCdc20_2	0.1389
p.E723K	TCGA-AA-3855	COAD	TCGA	RFRVHGE	LIG_APCC_ABBAyCdc20_2	0.0833
p.E723K	SIDM01667	B-Cell Non-Hodgkin's Lymphoma	GDSC	RFRVHGE	LIG_APCC_ABBAyCdc20_2	0.0833
p.T704M	TCGA-D1-A103	UCEC	TCGA	RFRVHGE	LIG_APCC_ABBAyCdc20_2	0.2222
p.R714L	TCGA-EE-A17Z	SKCM	TCGA	RFRVHGE	LIG_APCC_ABBAyCdc20_2	0.8428
p.E702K	DO10742	COAD	ICGC	RFRVHGE	LIG_APCC_ABBAyCdc20_2	0.1667
p.E702K	ACH-000220	Lymphoma	CCLE	RFRVHGE	LIG_APCC_ABBAyCdc20_2	0.1667
p.H712N	DO229046	LICA	ICGC	RFRVHGE	LIG_APCC_ABBAyCdc20_2	0.7423
p.R708C	DO50118	STAD	ICGC	RFRVHGE	LIG_APCC_ABBAyCdc20_2	0.8301
p.R708C	DO41644	UCEC	ICGC	RFRVHGE	LIG_APCC_ABBAyCdc20_2	0.8301
p.A716T	DO38404	STAD	ICGC	RFRVHGE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R714Q	SIDM02059	Colorectal Carcinoma	GDSC	RFRVHGE	LIG_APCC_ABBAyCdc20_2	0.7329
p.W719C	SIDM00057	Neuroblastoma	GDSC	RFRVHGE	LIG_APCC_ABBAyCdc20_2	0.1944
p.W719C	ACN	autonomic_ganglia	COSMIC	RFRVHGE	LIG_APCC_ABBAyCdc20_2	0.1944
p.T707M	SIDM00474	Ovarian Carcinoma	GDSC	RFRVHGE	LIG_APCC_ABBAyCdc20_2	0.3056
p.T707M	SIDM00126	Melanoma	GDSC	RFRVHGE	LIG_APCC_ABBAyCdc20_2	0.3056
p.W698C	ACH-000676	Brain Cancer	CCLE	RFRVHGE	LIG_APCC_ABBAyCdc20_2	0.0556
p.W698C	ACH-002389	Neuroblastoma	CCLE	RFRVHGE	LIG_APCC_ABBAyCdc20_2	0.0556
p.W698C	ACN	autonomic_ganglia	COSMIC	RFRVHGE	LIG_APCC_ABBAyCdc20_2	0.0556
p.P715S	ACH-002351	Non-Cancerous	CCLE	RFRVHGE	LIG_APCC_ABBAyCdc20_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UH99	SUN domain-containing protein 2	LIG_APCC_ABBAyCdc20_2	708:714	RFRVHGE	APC,CDC20,FZR1	0.8446	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons